W. Zeng

Association study of Plasmodium falciparum Acetyl-CoA Synthetase Mutations S868G and V949I with antimalarial drugs

This study investigates the association of PfACAS mutations S868G and V949I with antimalarial drug resistance using whole-genome sequencing and CRISPR/Cas9-engineered parasites.

TRPML1 gating modulation by allosteric mutations and lipids

This study identifies allosteric mutations and lipid interactions that modulate TRPML1 channel function, revealing structural insights into its regulation by lipids and potential therapeutic targets.

Acetyl-CoA Synthetase Mutations S868G and V949I Do Not Confer Resistance to Antimalarial Drugs in vitro in Plasmodium falciparum.

This study investigates whether mutations in PfACAS confer antimalarial drug resistance by engineering parasite lines with these mutations and testing their drug susceptibility in vitro.

Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48

This study evaluates the virological characteristics of BA.5.2.48 subvariant isolates, finding enhanced transmission and pathogenicity compared to BA.2, with divergent features among subvariants.

Characterization of the SARS-CoV-2 BA.5 Variants in H11-K18-hACE2 Hamsters

This study characterizes SARS-CoV-2 BA.5 variants in H11-K18 hACE2 golden hamsters, showing disease progression and severity similar to human infections, supporting the model's utility for research.

Cultivation of host-adapted Cryptosporidium parvum and Cryptosporidium hominis using enteroids for cryopreservation of isolates and transcriptomic studies of infection

This paper develops a method to cultivate and cryopreserve Cryptosporidium hominis and C. parvum using enteroids, showing improved transcriptomic responses compared to conventional cell systems.

RBP-J regulates homeostasis and function of circulating Ly6C lo monocytes

This study shows RBP-J regulates blood Ly6Clo monocytes and their derived lung macrophages by controlling CCR2 expression.

Homocysteine accelerates hepatocyte autophagy by upregulation of TFEB via DNMT3b-mediated DNA hypomethylation

This study shows homocysteine increases hepatocyte autophagy by upregulating TFEB through DNMT3b-mediated DNA hypomethylation of the TFEB promoter.

Complexes Formed by Mixing Tumor-derived Extracellular Vesicles with Polymeric Surfactants for Personalized Therapeutic Vaccine

This paper develops a therapeutic vaccine using tumor-derived extracellular vesicles modified with polymeric surfactants to enhance immunogenicity and efficacy against melanoma.

CARD8 negatively regulates NLRP1 inflammasome activation level by interaction with NLRP1

This study shows that the T60 variant of CARD8 inhibits NLRP1 inflammasome activation by interacting with NLRP1 and preventing inflammasome assembly.

Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology

This study shows Hsp27 binds phosphorylated Tau to prevent its aggregation and mitigate AD pathology.

Hetero-bivalent Nanobodies Provide Broad-spectrum Protection against SARS-CoV-2 Variants of Concern including Omicron

This paper develops hetero-bivalent nanobodies that neutralize multiple SARS-CoV-2 variants, including Omicron, and show protective effects in vivo.

Alternative 3' UTRs contributes to post-transcriptional gene expression regulation under high salt stress

The paper investigates how alternative 3' UTRs regulate gene expression in response to high salt stress in Spartina alterniflora, showing that 3' UTR lengthening enhances RNA stability and protein synthesis of stress-related genes.

Cryo-EM structures of human TMEM120A and TMEM120B

The paper reports cryo-EM structures of human TMEM120A and TMEM120B, revealing similar dimeric assemblies but no structural basis for their differing mechanosensing properties.

TMEM120 is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase

The paper presents the cryo-EM structure of TMEM120A, revealing it binds coenzyme A and shares structural features with ELOVL fatty acid elongase, suggesting a potential role in fatty acid metabolism rather than mechanosensation.

An Efficient Method to Quantify Structural Distributions in Heterogeneous cryo-EM Datasets

This paper introduces LCTC, a method to quantify structural distributions in heterogeneous cryo-EM datasets, showing improved performance over existing methods on simulated and experimental data.

Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

Potent in vitro Neutralization of SARS-CoV-2 by Hetero-bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain

This paper develops and characterizes SARS-CoV-2 RBD-specific alpaca nanobodies, showing improved binding affinity and neutralizing potency through bivalent engineering.

WRKY33-mediated indole glucosinolate metabolic pathway confers host resistance against Alternaria brassicicola

WRKY33 regulates indole glucosinolate biosynthesis and hydrolysis, enhancing resistance to Alternaria brassicicola in Arabidopsis and Brassica crops.

The conservation of a core virome in Aedes mosquitoes across different developmental stages and continents

This study identifies a vertically transmitted core virome in Aedes albopictus mosquitoes across developmental stages and continents, and finds a novel virus related to Yongsan bunyavirus 1.

Characterization of xyloglucan-specific fucosyltransferase activity in Golgi-enriched microsomal preparations from wheat seedlings

This paper investigates XyG biosynthesis in wheat seedlings and shows that wheat fucosyltransferase activity can fucosylate tamarind XyG in vitro, suggesting conserved XyG fucosylation mechanisms between monocots and dicots.

Vaccine-specific immune responses against Mycobacterium ulcerans infection in a low-dose murine challenge model

This study evaluates a prime-boost vaccine against Mycobacterium ulcerans in mice, finding that both the experimental ER vaccine and BCG provide significant protection through distinct immune profiles.

A Truly Injectable Neural Stimulation Electrode Made from an In-Body Curing Polymer/Metal Composite

The paper introduces an injectable neural stimulation electrode made from a polymer/metal composite that conforms to neural structures and performs similarly to traditional electrodes in rats and swine.

Identification of NAD-dependent xylitol dehydrogenase from Gluconobacter oxydans WSH-003

This paper identifies and characterizes an NAD-dependent xylitol dehydrogenase from Gluconobacter oxydans WSH-003, showing high activity for D-sorbitol to D-fructose conversion and distinct optimal conditions.

Bioluminscent Mycobacterium ulcerans, a tool to study host-pathogen interactions in a murine tail model of Buruli ulcer

This study uses bioluminescent Mycobacterium ulcerans in a mouse tail model to monitor Buruli ulcer progression and evaluate immune responses.

Aerobic removal of microcystin-LR by a novel native effective bacterial community designated as YFMCD4 isolated from Lake Taihu

This study identifies a bacterial community YFMCD4 that effectively removes microcystin-LR from water, with degradation rates influenced by temperature, pH, and concentration.

Common Piezo1 allele in African populations causes xerocytosis and attenuates Plasmodium infection

The paper identifies a common Piezo1 variant in African populations that causes xerocytosis and reduces Plasmodium infection.