S. Sinha

This paper identifies GIV as a NOD2-interactor that enhances bacterial sensing and signaling in macrophages, revealing how loss of function in the NOD2 1007fs variant impairs protective immune responses.

This study investigates the structural domains of FtsY in Sulfolobus acidocaldarius that facilitate SRP54 binding and membrane association during protein translocation.

The paper screens small molecules in MFS patient-derived VSMCs to identify GSK3β as a novel therapeutic target for aortic disease.

The paper analyzes tumor mutation burden (TMB) across 5,000 cancer patients and finds a universal distribution pattern, with implications for cancer risk and treatment response.

The paper develops a statistical mechanical theory to quantify intra-tumor heterogeneity using multi-region sequencing data, showing that ITH increases with spatial distance between regions.

The paper shows tracer particles accurately report local stresses in a growing multicellular spheroid without altering cancer cell dynamics.

This study demonstrates barrier-free liquid condensates of nanocatalysts that enhance catalytic efficiency through molecular confinement without physicochemical barriers.

The paper investigates how mechanical feedback in growing tissue monolayers leads to dynamical memory effects through cell division and intercellular interactions.

This study investigates how environmental factors like ionic strength and macromolecular crowding drive the phase separation of shell proteins and enzymes in prokaryotic microcompartments, enhancing enzyme activity.

This study identifies shared cellular and molecular features between severe COVID-19 and idiopathic pulmonary fibrosis, highlighting ER stress and AT2 cell dysfunction as key drivers.

The paper uses simulations to show that cell adhesion strength regulates non-monotonic growth in multicellular spheroids through a biomechanical feedback mechanism involving pressure fluctuations.

This study compares foetal and adult human epicardium using single-cell RNA sequencing to identify regenerative programs and their absence in adults, suggesting ways to enhance cardiac regeneration.

This study combines computational simulations and experimental assays to investigate how the domain II loop of PfAMA1 influences the binding kinetics of PfRON2, identifying key residues critical for the interaction.

The paper develops selective FPR2 agonists and shows they reduce non-resolving inflammation in asthma models.

This study uses molecular dynamics simulations to investigate the binding dynamics of galectin-3 with its ligand and a synthetic derivative, identifying key residues that enhance ligand residence time.

The paper identifies compartment-specific Tulp1 interactomes in photoreceptors, revealing interactions with Kif3a in the inner segment, Ribeye at the synapse, and MAP1B in both compartments.

This study shows FXR inhibition lowers ACE2 expression, reduces SARS-CoV-2 infection, and correlates with better clinical outcomes in COVID-19.

This paper introduces self-transfecting GMO-PMO chimeras for gene silencing, showing effectiveness in zebrafish and cancer cell inhibition of NANOG, enhancing therapeutic potential.

This paper introduces a droplet sorting system with new electrode and fluidic designs, enabling high-purity cell sorting and industrial-scale manufacturing.

The paper investigates if using a high tumor mutational burden (TMB) threshold for immunotherapy selection introduces sex bias, finding significant bias in melanoma but not in other cancers.

The paper investigates how immune factors influence the predictive power of tumor mutational burden (TMB) for immunotherapy response across cancer types.

The paper develops ATAC-Array, a low-cost chromatin accessibility assay, and shows it predicts pancreatic cancer prognosis based on chromatin accessibility patterns.

The paper identifies an epigenomic shift in the amygdala of virgin female mice exposed to pups, associated with the transition to maternal behaviors.

This study identifies distinct neutrophil states in COVID-19 compared to bacterial ARDS and shows dexamethasone alters these states, reducing mortality risk.

This study investigates how MUC1 interacts with influenza A virus in human airway epithelium and shows that MUC1 expression increases during infection, potentially limiting viral spread.

This paper develops a cell-free, densified collagen tubular graft that is mechanically strong, customizable, and supports cell incorporation for tissue replacement and disease modeling.

The paper identifies benztropine and DX600 as inhibitors of SARS-CoV-2 infection using a screening platform with human embryonic stem cell-derived cardiomyocytes.

The paper investigates whether SARS-CoV-2 uses circulating immune cells to spread in severe COVID-19 patients and finds that these cells are not actively infected and not a source of viral dissemination.

This study shows that HIV-1 broadly neutralizing antibodies and plasma from HIV-1 infected children can cross-neutralize SARS-CoV-2 by targeting conserved epitopes and glycans on the spike protein.