Author

T. Qi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1 Biophysics· 1 Cancer Biology· 1 Cell Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:host-pathogen & immune response· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Assay:cryo-EM· 1

Frequent Co-Authors

Y. Cao· 2 shared B. J. Staskawicz· 1 shared B. Vincent· 1 shared C. Liu· 1 shared C. Toth· 1 shared E. Nogales· 1 shared E. Rosta· 1 shared F. Liu· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersPharmacology & Toxicology

Y. Cao

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

CCL2 and Neuronal Inflammation: Implications for Neurodegenerative Diseases

z. zeng, q. mo, t. qi, S. Li

This review examines the role of CCL2 in microglial activation and neuronal inflammation, linking it to neurodegenerative diseases and discussing therapeutic strategies.

bioRxiv · Aug 16, 2023 · PreprintCell Biology

Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor.

P. J. Buigues, S. Gehrke, M. Badaoui, G. Mandana, T. Qi, G. Bottegoni, E. Rosta

This paper investigates the unbinding mechanism of muscarinic antagonists from hMR3, identifying structural bottlenecks and key residues involved in the process.

bioRxiv · Jan 3, 2023Biophysics

Population Dynamics of Immunological Synapse Formation Induced by Bispecific T-cell Engagers Predict Clinical Pharmacodynamics and Treatment Resistance

C. Liu, J. Zhou, S. Kudlacek, T. Qi, T. Dunlap, Y. Cao

bioRxiv · Apr 18, 2022Pharmacology & Toxicology

A multispecies framework for modeling adaptive immunity and immunotherapy in cancer

T. Qi, B. Vincent, Y. Cao

This paper develops a predator-prey model to simulate tumor-immune interactions and immunotherapy response using preclinical and clinical data.

bioRxiv · Feb 10, 2022Cancer Biology

Targeting interactions between the Galectin-3 intrinsically disordered and structured domains based on long time-scale accelerated molecular dynamics

S. Bhattacharya, M. Zhang, W. Hu, T. Qi, N. Heisterkamp

This study uses MD simulations and NMR to identify a binding cavity in Galectin-3's CTD that interacts with its disordered NTD, and designs an inhibitory peptide targeting this interface.

bioRxiv · Sep 27, 2021 · PreprintBiochemistry

Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ

R. Martin, T. Qi, H. Zhang, F. Liu, M. King, C. Toth, E. Nogales, B. J. Staskawicz

The paper presents the cryo-EM structure of the activated Roq1 NLR bound to XopQ, revealing direct effector recognition and resistosome activation mechanism.

bioRxiv · Aug 13, 2020Plant Biology

ADS-J1 Disaggregates Semen-derived Amyloid Fibrils

J. Li, Z. Yang, H. Liu, Y. Lan, T. Zhang, W. Li, T. Qi, Y. Qiu, L. Li, X. zhou, S. Liu, S. Tan

ADS-J1 disassembles semen-derived amyloid fibrils and prevents their re-aggregation, showing potential as a microbicide and treatment for amyloid diseases.

bioRxiv · Mar 30, 2018Pharmacology & Toxicology