Author

T. You

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Bioengineering· 1 Evolutionary Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Amirshaghaghi· 1 shared a. tsourkas· 1 shared B. A. Kugler· 1 shared B. Zhang· 1 shared C. Peng· 1 shared C. Qin· 1 shared F. Bai· 1 shared F. Liu· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBioengineering

A. Amirshaghaghi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Functional Diversification of Gene Duplicates under the Constraint of Protein Structure

K. Guo, Y. Yang, T. You, K. Zhu

This study examines gene duplication and divergence in GH50 agarases from Agarivorans ablus, showing structural and functional divergence while maintaining conserved backbone structures.

bioRxiv · Mar 6, 2024 · PreprintEvolutionary Biology

High-Intensity Interval Training Attenuates Impairment in Regulatory Protein Machinery of Mitochondrial Quality Control in Skeletal Muscle of Diet-Induced Obese Mice

J. B. Tincknell, B. A. Kugler, H. Spicuzza, H. Yan, T. You, K. Zou

This study shows that 10 weeks of high-intensity interval training improves mitochondrial respiration and quality control in diet-induced obese mice by altering Drp1 phosphorylation and autophagy markers.

bioRxiv · Jun 28, 2023Physiology

Phospholipase A2 inhibitor-loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression

Y. Wei, L. Yan, L. Luo, T. Gui, A. Amirshaghaghi, T. You, a. tsourkas, L. Qin, z. cheng

This study develops sPLA2 inhibitor-loaded micellar nanoparticles that reduce inflammation and slow osteoarthritis progression in human and mouse models.

bioRxiv · Jan 15, 2021Bioengineering

Structure of Mpro from COVID-19 virus and discovery of its inhibitors

Z. Jin, X. Du, Y. Xu, Y. Deng, M. Liu, Y. Zhao, B. Zhang, X. Li, L. Zhang, C. Peng, Y. Duan, J. Yu, L. Wang, K. Yang, F. Liu, , H. Yang

The paper identifies a mechanism-based inhibitor of the COVID-19 virus main protease through structure-assisted drug design and high-throughput screening.

bioRxiv · Feb 26, 2020Biochemistry