L.-Q. Wang

ALS-causing SOD1 mutations H46R and G85R form similar novel amyloid fibril structures and promote ferroptosis in cells

This study shows that two ALS-causing SOD1 mutations form similar amyloid fibrils that promote ferroptosis in neuronal cells.

Protein disulfide isomerase disassembles stress granules and blocks cytoplasmic aggregation of TDP-43 in ALS

This study shows that wild-type PDI disassembles stress granules and prevents TDP-43 mislocalization and aggregation in ALS, while abnormal PDI leads to amyloid fibrils and neuronal death.

Transcription regulation of SARS-CoV-2 receptor ACE2 by Sp1: a potential therapeutic target

This study identifies Sp1 as a regulator of ACE2 expression in response to SARS-CoV-2 infection and shows that targeting Sp1 reduces viral replication and tissue injury in Syrian hamsters.

Excess PrPC inhibits muscle cell differentiation via miRNA-enhanced liquid-liquid phase separation implicated in myopathy

Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its pathological conformational conversion

The paper determines the cryo-EM structure of human SOD1 amyloid fibrils, revealing conformational changes associated with ALS pathology.

Familial prion disease-related mutation E196K displays a novel amyloid fibril structure revealed by cryo-EM

The paper reports the cryo-EM structure of an amyloid fibril formed by the E196K mutation in human PrP, revealing a distinct conformation compared to wild-type PrP fibrils.

CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-κB pathways

This study shows that CREB1 regulates colorectal cancer cell plasticity by controlling lncRNA CCAT1 and the NF-κB pathway through interactions with CBP/p300 and p65.