W. Lyu

Cryo-EM structures of the human G-protein coupled receptor 1 (GPR1) - Gi protein complexes bound to the full-length chemerin and to its C-terminal nonapeptide

The paper reports cryo-EM structures of GPR1-Gi complexes bound to full-length chemerin and its C-terminal nonapeptide, revealing a 'two-site' interaction model and structural similarities to CMKLR1-Gi complexes.

Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming

This study shows histone lactylation counteracts senescence and skeletal muscle aging by reprogramming gene expression, with exercise enhancing lactylation and improving muscle function.

Abl2 mediates microtubule nucleation and repair via tubulin co-condensation.

This study identifies Abl2's role in microtubule nucleation and repair through tubulin co-condensation and direct interactions.

Rational evolution of a recombinant DNA polymerase for efficient incorporation of unnatural nucleotides by dual-site boosting

The paper improves a DNA polymerase's efficiency for unnatural nucleotide incorporation by identifying two key mutations through machine learning and mechanistic analysis.

On the accuracy of molecular simulation-based predictions of koff values: a Metadynamics study

This paper evaluates the accuracy of molecular simulations in predicting koff values for drug unbinding using metadynamics and QM/MM methods, finding discrepancies due to force field limitations.