Y. Ran

Optimization of gene knockout approaches and practical solutions to sgRNA selection challenges in hPSCs with inducible Cas9 system

This study optimizes gene knockout in hPSCs using an inducible Cas9 system and identifies effective sgRNAs by comparing experimental results with cleavage efficiency algorithms.

Integrated single-cell RNA-seq analysis revealed PTN secreted by fibroblasts acting on itself and macrophages via SDC4 ligand in myocardial hypertrophy

The paper identifies PTN secreted by fibroblasts acting on itself and macrophages via SDC4 in myocardial hypertrophy using scRNA-seq and experimental validation.

Rhamnolipid production from waste cooking oil using newly isolated halotolerant Pseudomonas aeruginosa M4

This study isolates a halotolerant Pseudomonas aeruginosa strain capable of degrading waste cooking oil and producing rhamnolipids, achieving high degradation rates and surfactant yields.

A new long-acting GLP-1 derivative 6- KTP ameliorates body weight and lipid metabolism in DIO mice

This study evaluates a new long-acting GLP-1 derivative, 6-KTP, showing it reduces body weight and improves lipid metabolism in diet-induced obese mice.

High affinity interactions and signal transduction between Aβ oligomers and TREM2

This study investigates the high-affinity interaction between TREM2 and Aβ oligomers, showing that AD-associated TREM2 variants have reduced signaling and internalization capacity.