W. Ji

Integrated single-cell RNA-seq analysis revealed PTN secreted by fibroblasts acting on itself and macrophages via SDC4 ligand in myocardial hypertrophy

The paper identifies PTN secreted by fibroblasts acting on itself and macrophages via SDC4 in myocardial hypertrophy using scRNA-seq and experimental validation.

A single mutation in dairy cow-associated H5N1 viruses increases receptor binding breadth

This study identifies a single mutation in H5N1 viruses from dairy cows that increases receptor binding breadth to avian receptors, suggesting potential for expanded host range.

CAMSAP3 Forms Dimers via its lapha-helix Domain that Directly Stabilize Non-centrosomal Microtubule Minus Ends

This study identifies how CAMSAP3 dimerizes via its C-terminal alpha-helix to stabilize non-centrosomal microtubule minus ends through enhanced CKK domain binding.

The protective roles of Eugenol on type 1 diabetes mellitus through NRF2 mediated oxidative stress pathway

This study investigates the protective effects of eugenol on type 1 diabetes mellitus by activating the NRF2 pathway, reducing oxidative stress and apoptosis in pancreatic β cells.

Super Pangenome of Grapevines Empowers Improvement of the Oldest Domesticated Fruit

The paper assembles and annotates haplotype-resolved genomes of grapevines to uncover genetic diversity and disease resistance mechanisms, identifying structural variants linked to downy mildew resistance.

Sec23IP recruits the Cohen syndrome factor VPS13B/COH1 to ER exit site-Golgiinterface for tubular ERGIC formation

This study identifies Sec23IP as a VPS13B adaptor that recruits VPS13B to ER exit sites-Golgi interfaces, promoting tubular ERGIC formation and affecting procollagen export, linking it to Cohen syndrome pathogenesis.

Optogenetic control of pheromone gradients and mating behavior in budding yeast

The paper uses optogenetic tools to control pheromone gradients in budding yeast, enabling spatial regulation of mating behavior and cell fusion.

Rewiring Cancer Drivers to Activate Apoptosis

This paper introduces TCIPs, molecules that activate cell death by rewiring cancer drivers, showing efficacy against DLBCL and potential for broader therapeutic applications.

MYPT1 is a non-canonical AKAP that tethers PKA to the MLCP signaling node

This study identifies MYPT1 as a non-canonical AKAP that directly interacts with PKA-R variants to tether PKA to the MLCP signaling node.

A complex containing RhoBTB3-SHIP164-Vps26B promotes the biogenesis of early endosome buds at Golgi-endosome contacts

The paper identifies a protein complex that promotes early endosome bud biogenesis through lipid transport at Golgi-endosome contacts.

Specialized metabolism by trichome-preferentially-expressed Rubisco and fatty acid synthase components

The paper identifies and validates two trichome-preferentially-expressed genes involved in acylsugar biosynthesis in solanaceous plants through gene expression analysis and virus-induced gene silencing.

Tex2 is required for lysosomal functions at TMEM55-dependent ER membrane contact sites

This study identifies Tex2 as a tubular ER protein required for lysosomal functions through its interaction with TMEM55 at ER-LE/lys MCSs.

A self-blinking DNA probe for 3D superresolution imaging of native chromatin

This paper introduces a self-blinking DNA probe for 3D superresolution imaging of native chromatin in live cells, revealing chromatin organization and decompaction dynamics.

Population Transcriptome and Phenotype Reveal that Rht-D1b Contributes a Larger Seedling Root to Modern Bread Wheat

The paper investigates the impact of GR alleles on wheat root systems, finding that Rht-D1b increases seedling root size by enhancing cell length and meristem size, while Rht-B1b has no significant effect on root traits.

Covalent Disruptor of YAP-TEAD Association Suppresses Defective Hippo Signaling

This paper develops a covalent inhibitor of the YAP-TEAD complex, demonstrating its ability to suppress Hippo signaling defects and inhibit cancer cell growth.

SARS-CoV-2 variant B.1.1.7 caused HLA-A2+ CD8+ T cell epitope mutations for impaired cellular immune response

This study identifies mutations in SARS-CoV-2 variant B.1.1.7 that reduce HLA-A2 restricted CD8+ T cell epitope binding and impair cellular immune responses.

Wall-associated Receptor Kinase and The Expression Profiles in Wheat Responding to Fungal Stress

This study classifies wheat WAKs and WAKLs, identifies structural features, and shows that TaWAK75 and TaWAK76b are involved in resistance to Bgt.

Resurrection of human endogenous retroviruses during aging reinforces senescence

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

Trans-Golgi network-lipid droplet contacts maintain the TGN integrity and function via lipid transfer activities of VPS13B

This study identifies VPS13B as a mediator of TGN-LD membrane contact sites, showing its role in lipid transfer and TGN integrity through specific domains.

A potent neutralizing nanobody against SARS-CoV-2 with inhaled delivery potential

The paper identifies a potent neutralizing nanobody against SARS-CoV-2 with high activity and stability for inhaled delivery.

Drone-derived canopy height predicts biomass across non-forest ecosystems globally

This study shows drone-derived canopy height can predict aboveground biomass in non-forest ecosystems globally, demonstrating the generalizability of photogrammetric methods across plant types and environments.

Single-cell atlas of a non-human primate reveals new pathogenic mechanisms of COVID-19

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

Identification and Expression Analysis of Heat Shock Proteins in Wheat Infected with Powdery Mildew and Stripe Rust

This study classifies and analyzes the expression of heat shock proteins in wheat infected with powdery mildew and stripe rust, revealing structural diversity and differential expression patterns.

Two distinct actin filament populations have effects on mitochondria, with differences in stimuli and assembly factors

The paper identifies two distinct actin filament populations with different assembly factors and effects on mitochondrial dynamics in response to calcium and depolarization.

Extensive adaptive immune response of AAVs and Cas proteins in non-human primates

The paper investigates pre-existing adaptive immune responses to CRISPR Cas proteins and AAVs in non-human primates and finds such immunity is普遍存在 regardless of Cas proteins or AAVs.

Candidate Gene Networks for Acylsugar Metabolism and Plant Defense in Wild Tomato Solanum pennellii

The paper identifies candidate genes and networks involved in acylsugar metabolism and plant defense in Solanum pennellii through transcriptomic analysis and gene co-expression networks.

Coordination between discrete Mitotic Arrest Deficient 1 (MAD1) domains is required for efficient mitotic checkpoint signaling

This study identifies novel interactions of MAD1 domains with MAD2 conformers and their regulation by MPS1 kinase, revealing mechanisms for mitotic checkpoint signaling.