Author

S.-Y. Chang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4 Microbiology· 4 Bioengineering· 3 Cell Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:human· 7 Research Focus:cell type annotation· 5 Research Focus:host-pathogen & immune response· 4 Approach:statistical model· 4 Assay:whole-genome sequencing· 4 Organism:mouse· 3 Organism:virus· 3

Frequent Co-Authors

P.-J. Chen· 5 shared S.-H. Yeh· 5 shared T.-L. Chao· 5 shared H.-Y. Wang· 4 shared J.-H. Tai· 4 shared Y.-M. Tsai· 4 shared H.-C. Kao· 3 shared M. Hashimoto· 3 shared

Activity by Year

2020-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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5 shared papersEvolutionary Biology

P.-J. Chen

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15 papers

Recent·Most cited

Cross-institutional HER2 assessment via a computer-aided system using federated learning and stain composition augmentation

C.-H. Yang, Y.-A. Chen, S.-Y. Chang, Y.-H. Hsieh, Y.-L. Hung, Y.-W. Lin, Y.-H. Lee, C.-H. Lin, Y.-C. Lin, Y.-S. Lu, Y.-Y. Lin

This paper develops a HER2 assessment system using federated learning and stain composition augmentation, achieving over 90% accuracy across two institutions with improved generalizability.

bioRxiv · Jan 17, 2024 · PreprintPathology

Organ-on-a-Chip Fabrication using Dynamic Photomask

T. Ching, S.-Y. Chang, Y.-C. Toh, M. Hashimoto

This paper introduces a dynamic photomask system for rapid organ-on-a-chip fabrication, enabling real-time design modifications and improved manufacturability.

bioRxiv · Nov 22, 2023Bioengineering

Atlas of Fshr Expression from Novel Reporter Mice

H.-Q. Chen, H. Fang, J.-T. Liu, S.-Y. Chang, L.-B. Cheng, M.-X. Sun, J.-R. Feng, Z. Liu, X.-L. Li, Y. Zhang, C. J. Rosen, P. Liu

This paper develops Fshr-ZsGreen knockin reporter mice to study FSHR expression in vivo, revealing novel extragonadal expression patterns and expanding the known physiological roles of the FSH-FSHR pathway.

bioRxiv · Nov 5, 2023Cell Biology

3D Bioprinting Using Poly(ethylene-glycol)-dimethacrylate (PEGDMA) Composite

S.-Y. Chang, J. Z. W. Lee, A. S. Ranganath, T. Ching, M. Hashimoto

This paper demonstrates the use of PEGDMA as a composite bioink to enhance mechanical properties in SLA bioprinting, supporting cell proliferation in vitro.

bioRxiv · Oct 19, 2023 · PreprintBioengineering

Antagonistic pleiotropy plays an important role in governing the evolution and genetic diversity of SARS-CoV-2

D.-C. Lee, J.-H. Tai, H.-F. Lin, T.-L. Chao, Y. Ruan, Y.-W. Cheng, Y.-C. Chou, Y.-Y. Lin, S.-Y. Chang, P.-J. Chen, S.-H. Yeh, H.-Y. Wang

The paper examines how antagonistic pleiotropy influences SARS-CoV-2 evolution and genetic diversity by analyzing genomic mutations and their functional impacts.

bioRxiv · Feb 10, 2023Evolutionary Biology

Spatial and Temporal Origin of The Third SARS-Cov-2 Outbreak in Taiwan

J.-H. Tai, Y. K. Low, S. C.-L. Wang, H.-F. Lin, T.-Y. Wang, Y.-Y. Lin, C. Foster, S. J. van Hal, Y.-Y. Lai, S.-H. Yeh, S.-Y. Chang, P.-J. Chen, S.-M. Chaw

This study identifies the third SARS-CoV-2 outbreak in Taiwan as originating from a European lineage introduced in February 2021, not from the US as previously thought.

bioRxiv · Jul 4, 2022 · PreprintEvolutionary Biology

Equilibrative Nucleoside Transporter 3 is an IFN-stimulated Gene that Facilitates Viral Genome Release

Y.-T. Hsieh, T.-L. Tsai, C.-C. Tu, S.-Y. Huang, J.-W. Heng, P.-Y. Tsai, T.-L. Chao, Y.-M. Tsai, P.-C. Chang, C.-K. Lee, G.-Y. Yu, S.-Y. Chang, I. Dzhagalov, C.-L. Hsu

This study identifies ENT3 as an IFN-stimulated gene that supports viral genome release, showing its role in viral entry and replication.

bioRxiv · Apr 27, 2022 · PreprintImmunology

Biomimetic Vasculatures by 3D-Printed Porous Molds

T. Ching, j. vasudevan, S.-Y. Chang, H. Y. Tan, C. T. Lim, J. G. Fernandez, J. J. Ng, Y.-C. Toh, M. Hashimoto

This paper introduces a 3D-printed porous mold technique to create cell-laden, perfusable vascular models that mimic biological and anatomical features of blood vessels.

bioRxiv · Sep 27, 2021Bioengineering

Signatures of adaptive evolution during human to mink SARS CoV2 cross species transmission inform estimates of the COVID19 pandemic timing

J.-H. Tai, S.-M. Chaw, H.-Y. Sun, Y.-C. Tseng, G. Li, S.-Y. Chang, S.-H. Yeh, P.-J. Chen, H.-Y. Wang

The paper analyzes SARS-CoV-2 sequences from minks and humans to determine if adaptive evolution occurred before the pandemic, suggesting the virus may have circulated in humans for at least six months prior to the Wuhan outbreak.

bioRxiv · Sep 15, 2021 · PreprintEvolutionary Biology

Impact of glycosylation on a broad-spectrum vaccine against SARS-CoV-2

H.-Y. Huang, H.-Y. Liao, X. Chen, S.-W. Wang, C.-W. Cheng, M. Shahed-Al-Mahmud, T.-H. Chen, J. M. Lo, Y.-M. Liu, Y.-M. Wu, H.-H. Ma, Y.-H. Chang, H.-Y. Tsai, Y.-C. Chou, Y.-P. Hsueh, , C.-H. Wong

This study shows that trimming N-glycans from the SARS-CoV-2 spike protein enhances immune responses and protection against variants in hACE2 mice.

bioRxiv · May 25, 2021 · PreprintMicrobiology

KAHRP dynamically relocalizes to remodeled actin junctions and associates with knob spirals in P. falciparum-infected erythrocytes

C. P. Sanchez, P. Patra, S.-Y. Chang, C. Karathanasis, L. Hanebutte, N. Kilian, M. Cyrklaff, M. Heilemann, U. S. Schwarz, M. Kudryashev, M. Lanzer

This study uses super-resolution microscopy to show KAHRP relocalizes to remnant actin junctions and associates with spiral scaffolds in P. falciparum-infected erythrocytes.

bioRxiv · May 12, 2021Microbiology

D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Viral Transmission via Enhanced Furin-mediated Spike Cleavage

Y.-W. Cheng, T.-L. Chao, C.-L. Li, S.-H. Wang, H.-C. Kao, Y.-M. Tsai, H.-Y. Wang, C.-L. Hsieh, P.-J. Chen, S.-Y. Chang, S.-H. Yeh

This study shows the D614G substitution in SARS-CoV-2 spike protein increases viral transmission by enhancing furin-mediated cleavage, leading to more syncytium formation and higher virus titers.

bioRxiv · Jan 27, 2021Microbiology

Bridging the gap between in silico and in vivo: modeling opioid disposition in a kidney proximal tubule microphysiological system

T. Imaoka, W. Huang, S. Shum, D. W. Hailey, S.-Y. Chang, A. Chapron, C. K. Yeung, J. Himmelfarb, N. Isoherranen, E. J. Kelly

This study predicts opioid kidney clearance and systemic disposition in CKD patients using a microphysiological system and PBPK modeling.

bioRxiv · Dec 4, 2020Pharmacology & Toxicology

Distinct Inductions of and Responses to Type I and Type III Interferons PromoteInfections in Two SARS-CoV-2 Isolates

F. Hsin, T.-L. Chao, Y.-R. Chan, H.-C. Kao, W.-D. Liu, J.-T. Wang, Y.-H. Pang, C.-H. Lin, Y.-M. Tsai, J.-Y. Lin, S.-Y. Chang, H. M. Liu

This study compares two SARS-CoV-2 isolates and finds they induce weak antiviral responses and are less neutralized by antibodies.

bioRxiv · Apr 30, 2020 · PreprintMicrobiology

The origin and underlying driving forces of the SARS-CoV-2 outbreak

S.-M. Chaw, J.-H. Tai, S.-L. Chen, C.-H. Hsieh, S.-Y. Chang, S.-H. Yeh, W.-S. Yang, P.-J. Chen, H.-Y. Wang

This paper analyzes SARS-CoV-2 genetic variation and finds evidence of intergenomic recombination, relaxed selection, and possible cryptic circulation in humans before the 2020 outbreak.

bioRxiv · Apr 12, 2020Evolutionary Biology