Cancer Immunotherapy and Biomarkers

Evolution of immune infiltration and immune triad formation across early melanoma progression

The paper investigates immune infiltration and triad formation in early melanoma progression using spatial transcriptomics, finding increased immune engagement in Stage I lesions compared to Stage 0.

CD4 T cell surface architecture is associated with response to anti-PD-1 therapy in non-small cell lung cancer

The paper shows that CD4 T cell surface protein organization predicts response to anti-PD-1 therapy in NSCLC, outperforming protein abundance alone.

PD-L1 deletion or blockade regulate macrophage antigen presentation and checkpoint molecule surface levels

This study investigates how PD-L1 deletion or blockade affects macrophage antigen presentation and checkpoint molecule levels in different polarization states.

A matrikine organizes the dendritic cell- T cell triads that build tertiary lymphoid structures

This study identifies versikine, a matrikine derived from VCAN proteolysis, as essential for organizing dendritic cell-T cell triads in tertiary lymphoid structures and enhancing antitumor immunity.

Spatially enforced engagement of PD-1⁺ T cells with AXL⁺ cells reprograms the tumor microenvironment and overcomes anti-PD-1 resistance

This study develops a bispecific antibody that enhances T-cell engagement with AXL+ cells, improving anti-PD-1 therapy efficacy in HNSCC by remodeling the tumor microenvironment.

Cancer cells hijack mitochondria from Bhlhe40+ T cells for immune evasion

The paper identifies the Bhlhe40-S100a4 cascade as a key regulator of cancer cell mitochondrial transfer from T cells, offering a target for immunotherapy.

Matrix stiffness shapes immunometabolic states and response to PD-1 blockade in gastric cancer

This study shows that matrix stiffness in gastric cancer affects immunometabolic states and response to PD-1 blockade, with softer matrices improving treatment efficacy.

Targeting alpha-ketoglutarate starvation within the tumor-immune microenvironment rescues T cell effector function in cancer immunotherapy

This study shows that supplementing alpha-ketoglutarate (aKG) improves T cell function and immunotherapy effectiveness in NSCLC by reversing epigenetic changes associated with T cell exhaustion.

Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses

This study shows that colorectal cancers with different metastatic potential trigger distinct early T cell responses, with non-metastatic tumors inducing cytotoxic T cells and pro-metastatic tumors causing hypoactivated T cells.

Novel retinoic acid receptor-related orphan receptor gamma inverse agonist enhances checkpoint blockade in hepatocellular carcinoma: a preclinical mouse study

This study shows that inhibiting RORgamma enhances PD-L1 blockade efficacy in HCC by reducing neutrophil recruitment and increasing PD-L1 expression.

Whole-genome sequencing reveals tumor T-cell infiltration associated with immunotherapy outcomes

The paper develops a DNA-based T-cell infiltration score from whole-genome sequencing to predict immunotherapy response and survival.

ICOS blockade alleviates immune suppression in breast tumor microenvironment

This study shows that blocking ICOS reduces immune suppression in breast tumors by altering Treg and CD8 T cell dynamics, enhancing anti-tumor immunity.

Computational modeling of breast cancer metastases predicts response to dual checkpoint inhibition and reveals spatially-informed treatments

The paper develops an agent-based model of breast cancer metastases to predict responses to dual checkpoint inhibition and identifies spatially-informed treatment strategies.

ResponseVerdict overturns computationally validated immunotherapy signatures, recovers their missed responders and outperforms every published response predictor

ResponseVerdict improves immune checkpoint blockade response prediction by outperforming existing signatures and predictors using data from prior studies.

MHC-I downregulation is associated with immune-evasion in breast cancers with heterogeneous activation of epithelial-mesenchymal plasticity

The paper shows that in mixed E-qM breast tumors, qM cancer cells create immunosuppressive niches leading to MHC-I downregulation and immune evasion.

CXCL9-Dependent Immune Networks of Spontaneous Tertiary Lymphoid Structures in a Murine Subcutaneous Tumor Model

This study develops a subcutaneous tumor model that naturally forms tertiary lymphoid structures (TLS) and identifies CXCL9 as a key regulator of TLS formation and function.

mtDNA Activates AIM2-Mediated PANoptosis in Interstitial Macrophages to Promote Immune Checkpoint Inhibitor Pneumonitis

This study shows that mtDNA triggers AIM2-mediated PANoptosis in lung interstitial macrophages, contributing to immune checkpoint inhibitor pneumonitis.

Cellular proximity and conditional coordination in the colorectal and pancreatic tumor microenvironment: a patient-level analysis of multiplexed imaging

The paper analyzes spatial organization of immune and epithelial cells in colorectal and pancreatic cancers using multiplexed imaging, finding differences in conditional coordination and proximity between disease subtypes.

FLASH X-rays preserve neutrophil chromatin to boost antitumor immunity

This study shows FLASH X-rays preserve neutrophil chromatin, reducing NET formation and enhancing antitumor immunity when combined with anti-PD-1 therapy.

Deep-learning-driven tumor microenvironment profiling improves immunotherapy response prediction

EcoNet improves immunotherapy response prediction by modeling tumor microenvironment signaling networks, outperforming existing methods in AUC and stratifying ccRCC patients by clinical outcome.

Alcohol, Tobacco, and HPV exposure synergistically regulate promoter methylation of PD-L1 related genes in Head and Neck Squamous Cell Carcinoma

This study examines how combined exposure to alcohol, tobacco, and HPV affects promoter methylation of PD-L1 related genes in HNSCC, revealing synergistic effects and immune microenvironment changes.

Spatiotemporal profiling of T cell repertoires in Lynch syndrome reveals convergent immune responses through neoplastic progression

This study profiles T cell repertoires in Lynch syndrome patients to show convergent immune responses during neoplastic progression.

Regional reproducibility of immune expression programs in glioblastoma and implications for single-biopsy assessment

The paper assesses the reproducibility of immune expression programs across glioblastoma biopsies and finds that IFN and MHC-I show the highest consistency.

Genetic dissection of DNA damage response pathways reveals divergent modulation of PD-1 blockade response in colorectal cancer

This study identifies DDR gene alterations that modulate PD-1 blockade response in MSS colorectal cancer, showing that some defects enhance immunotherapy while others reduce benefit.

Functional Deorphanization of Tumor-reactive TCRs Uncovers a Landscape of Shared, Immune Dominant Antigens across Cancers

This study introduces TWISTAR, a platform to identify tumor-reactive TCRs and their antigens, revealing shared immunogenic targets across cancers and immune dominance.

Engineered CTLA-4 targeting chimeras for targeted protein degradation and immune synapse reprogramming

This paper introduces cTACs, synthetic molecules that degrade PD-L1 across immune and tumor cells, enhancing T cell activation and tumor suppression in vivo.

Early dynamics of a neutrophil interferon program drive immunotherapy resistance and limit durable anti-tumor immunity

This study identifies an early neutrophil interferon program that predicts resistance to anti-PD1 therapy and limits durable anti-tumor immunity.

Tumor cell-intrinsic mtDNA instability drives cGAS-dependent temporal remodeling of the melanoma immune microenvironment

This study shows that tumor cell-intrinsic mtDNA instability drives temporal changes in the melanoma immune microenvironment through cGAS, affecting immune cell states and therapeutic response.

Patient-Derived Melanoma Organoids Preserve Tumor-Immune Heterogeneity and Reveal Context-Dependent Responses to Immune Checkpoint Blockade

This study establishes patient-derived melanoma organoids (PDMOs) that retain tumor-immune heterogeneity and show context-dependent responses to immune checkpoint blockade.

Tissue resident CD4+ memory T-cells mark response to immune checkpoint inhibition in high-grade glioma

The paper identifies CD4+ tissue-resident memory T-cells as markers of response to immune checkpoint inhibition in high-grade glioma.