Discover, rate, and discuss biology preprints.

This paper develops a type 2 diabetes model in nude athymic rats using high-fat diet and streptozotocin, showing features of diabetic cardiomyopathy suitable for xenograft studies.

The paper reports the first detection of Bagaza virus in wild birds in Portugal in 2021, showing high similarity to previously reported strains.

The paper investigates Spred2 expression in urothelial tumors and finds it negatively correlates with ERK activation and Ki67 index in non-invasive papillary carcinoma.

This study shows cigarette smoke causes lung lymphatic thrombosis and dysfunction in mice and humans, linking it to emphysema pathogenesis.

This paper introduces PICS, a method that uses deep learning to infer collagen distribution from unlabeled tissue images, matching ground truth metrics.

This study examines ACE-2 expression and shedding in placental tissues and maternal serum during SARS-CoV-2 infection in pregnancy, finding increased soluble ACE-2 in third-trimester infections.

This study uses ribosome profiling to analyze PRRSV gene expression and reveals temporally regulated frameshifting and novel transcripts.

This paper validates a cervical lesion proportion measure using a gridded imaging technique to quantify cervical pathology in women with genital schistosomiasis, showing high inter- and intra-observer reliability.

This study shows that excessive IL-6 in acetaminophen-induced liver failure causes immune suppression, reduced cerebral blood flow, and increased mortality in mice.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

The paper shows that leukocyte proliferation drives Leigh syndrome pathology in Ndufs4(KO) mice, and leukocyte depletion prevents CNS lesions and extends survival.

This study develops a semi-automated method for tumor budding assessment in colorectal cancer and compares it with manual methods, finding strong correlation and higher detection rates with the new approach.

This paper shows that photochemical pre-bleaching reduces autofluorescence in archival prostate tissues, improving multiplex immunofluorescence signal-to-noise.

This study examines structural, cellular, and viscoelastic changes in the ACL of a murine PTOA model, finding ECM modifications and altered biomechanics.

This study shows EGFR inhibition reduces vascular calcification by blocking CAV1-dependent calcifying EV release in CKD mice and humans.

The paper uses spatial proteomics to show that the IPF fibroblastic focus is a major site of collagen biosynthesis with distinct ECM composition compared to surrounding tissues.

This study investigates how Xanthomonas vasicola pv. musacearum spreads within banana mats and identifies factors influencing its colonization of suckers.

This study identifies fibro-adipogenic progenitors (FAPs) as the cells-of-origin for neurogenic heterotopic ossifications (NHO) following spinal cord injury, showing their reprogramming into osteoblasts.

The paper identifies a wound-like tumor periphery in breast cancer as a uniparameter marker predicting multidrug nonresponse and poor prognosis across molecular subtypes.

This paper develops a multimodal deep learning model for cancer prognosis that integrates gene expression, DNA methylation, histopathological imaging, and clinical data, showing improved performance over unimodal approaches.