X. Liao

Synergically enhanced anti-tumor immunity of in vivo CAR by circRNA vaccine boosting

This study develops circRNA-based in vivo CAR and vaccines that synergistically enhance anti-tumor immunity in mice.

Skeleton-forming responses of reef-building corals under ocean acidification

This study examines how four coral species form skeletons under acidified conditions, revealing diverse strategies and damage patterns.

Alanine and glutamate catabolism ensure proper sporulation by preventing premature germination and providing energy respectively

The paper identifies roles for alanine and glutamate catabolism in bacterial sporulation, showing they prevent premature germination and provide energy, respectively.

Supercontinuum intrinsic fluorescence imaging heralds free view of living systems

This paper introduces a supercontinuum fluorescence imaging technique that enables non-invasive, high-content analysis of living systems across multiple biological processes and species.

Unbiased Complete Estimation of Chloroplast Number in Plant Cells Using Deep Learning Methods

This paper introduces a deep learning method for accurate 3D chloroplast counting in plant cells, achieving over 95% accuracy compared to manual methods.

RNA sequencing identifies lung cancer lineage and facilitates drug repositioning

This paper uses RNA sequencing to classify lung cancer subtypes and identifies drug repositioning opportunities based on lineage-specific responses.

Osteoblast-intrinsic defect in glucose metabolism impairs bone formation in type II diabetic mice

This study shows that impaired glucose metabolism in osteoblasts causes reduced bone formation in type 2 diabetic mice, and identifies potential therapeutic targets.

The Cul5 E3 Ligase Complex Is a Key Negative Feedback Regulator of TCR/IL2 Signaling and Anti-Tumor Activity in CD8+ T Cells

This study identifies Cul5 as a negative feedback regulator of CD8+ T cell signaling and anti-tumor activity, showing its knockout enhances tumor control through proteomic and signaling changes.

Base Editor-Mediated Pooled Screening of Functional Mutations in Bacteria for Industrial Phenotypes

The paper develops a base editor-mediated pipeline in E. coli to screen for functional single nucleotide variants under industrial stress conditions, identifying known and novel mutations.

Full-length transcriptome maps of reef-building coral illuminate the molecular basis of calcification, symbiosis, and circadian genes

The paper sequenced full-length transcriptomes of four reef-building corals to uncover molecular mechanisms of calcification, symbiosis, and circadian genes.

A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia

The paper studies a genetic disorder caused by MECOM haploinsufficiency to identify a transcriptional network critical for HSC maintenance, which is also co-opted in high-risk leukemias.

Transcriptomics analysis reveals intracellular mutual regulation of coral-zooxanthella holobionts

The paper analyzes transcriptomes and small RNAs of corals and their symbionts to reveal mutual gene regulation mechanisms and miRNA roles in host-symbiont interactions.

Wound-like tumor periphery in human breast cancer predicts a convergent drug nonresponse

The paper identifies a wound-like tumor periphery in breast cancer as a uniparameter marker predicting multidrug nonresponse and poor prognosis across molecular subtypes.

Kinetics of self-assembly of inclusions due to lipid membrane thickness interactions

This paper computes the time scale for protein inclusion self-assembly on lipid membranes as a function of initial separation using Langevin dynamics and PDEs, finding coalescence occurs in hundreds of milliseconds for separations of ~100 nm.

Extensions of the worm-like-chain model to tethered active filaments under tension

The paper extends the worm-like-chain model to analyze tethered active filaments under tension, deriving force-extension relationships and mean square deflections under different boundary conditions.

Comparative analyses of 3654 chloroplast genomes unraveled new insights into the evolutionary mechanism of green plants

The paper compares 3654 chloroplast genomes to uncover evolutionary patterns in green plants, identifying gene clusters and IR expansions.

Knowledge-guided analysis of ‘omics’ data using the KnowEnG cloud platform

KnowEnG is a cloud-based platform that provides tools for analyzing genomics data using knowledge-guided data-mining and machine learning, demonstrating its utility in cancer research.

Coloring Single Nanoparticle Trajectory in Live Cell with its Own History: a Presuppositionless Approach

The paper introduces a presuppositionless method to analyze single nanoparticle trajectories by leveraging their historical data, revealing spatiotemporal patterns without predefined models.

Cell rounding causes genomic instability by dissociation of single-stranded DNA-binding proteins

The paper identifies cell rounding as a source of genomic instability through DNA-binding protein dissociation, observed in normal, cancer, and stem cells.

WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death

This study identifies WDR45's role in neurodegeneration by showing its regulation of ER homeostasis and neuronal death through autophagy defects.