Author

H. Lai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Cancer Biology· 2 Immunology· 2 Plant Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2

Frequent Co-Authors

J. Wang· 3 shared C. Zhu· 2 shared D. Zhou· 2 shared J. Tong· 2 shared L. A. G. Lucas· 2 shared A. K. Glaser· 1 shared A. K. Hempton· 1 shared A. Upadhyaya· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersBioengineering

J. Wang

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10 papers

Recent·Most cited

MIPDB: A maize image-phenotype database with multi-angle and multi-time characteristics

P. Wang, J. Chang, W. Deng, B. Liu, H. Lai, Z. Hou, L. Dong, Q. Chen, Y. Zhou, Z. Zhang, H. Liu, J. Ruan

The paper introduces MIPDB, a maize image-phenotype database with multi-angle and multi-time images, providing a high-quality dataset for deep learning-based phenomics research.

bioRxiv · Apr 26, 2024 · PreprintPlant Biology

Comparative transcriptomic and lipidomic analysis of fatty acid accumulation in three Camellia oleifera varieties during maturation

d. Yang, R. Wang, H. Lai, Y. Chen, Y. He, C. Xun, Y. Zhang, Z. He

This study compares transcriptomic and lipidomic profiles of three Camellia oleifera varieties during seed maturation, linking fatty acid composition to gene expression patterns.

bioRxiv · Mar 7, 2024Plant Biology

RNA Splicing Junction Landscape Reveals Abundant Tumor-Specific Transcripts in Human Cancer

Q. Li, Z. li, B. Chen, J. Zhao, H. Yu, J. Hu, H. Lai, H. Zhang, Y. Li, Z. Meng, Z. Hu, S. Huang

This study analyzes RNA splicing junctions in 34,775 samples to identify 29,051 tumor-specific transcripts linked to cancer stemness, poor prognosis, and immunotherapy targets.

bioRxiv · Feb 6, 2024Cancer Biology

Distinct Microstructural Heterogeneities Underpin Specific Micromechanical Properties in Human ACL Femoral and Tibial Entheses

J. Fang, X. Wang, H. Lai, W. Li, z. pan, R. Mao, Y. Yan, C. Xie, J. Lin, W. Sun, R. Li, J. Wang, J. Dai, K. Xu, X. Yu, , X. Dai

This study identifies distinct microstructural and biomolecular features in ACL femoral and tibial entheses that contribute to their specific mechanical properties.

bioRxiv · Aug 16, 2023 · PreprintBioengineering

The majority of microorganisms in gas hydrate bearing subseafloor sediments ferment macromolecules

C. Zhang, Y.-X. Fang, X. Yin, H. Lai, Z. Kuang, T. Zhang, X.-P. Xu, G. Wegener, J.-H. Wang, X. Dong

This study identifies fermentation of macromolecules as the dominant energy source for microorganisms in gas hydrate-bearing subseafloor sediments.

bioRxiv · May 19, 2022Microbiology

Parallel lipid-carried epitope pillars enhance stimulation of chimeric antigen receptor T cells

J. Tong, H. Lai, J. Wang, C. Zhu, X. Mai, D. Zhou

This study shows that glycosylphosphatidylinositol-anchored MUC1 epitope pillars enhance chimeric antigen receptor T cell stimulation, with tandem repeat sequences showing greater activity.

bioRxiv · Apr 15, 2022 · PreprintImmunology

Three-dimensional residual channel attention networks denoise and sharpen fluorescence microscopy image volumes

J. Chen, H. Sasaki, H. Lai, Y. Su, J. Liu, Y. Wu, A. Zhovmer, C. A. Combs, I. Rey-Suarez, H. Chang, C. C. Huang, X. Li, M. Guo, S. Nizambad, A. Upadhyaya, , H. Shroff

This paper applies RCAN to enhance fluorescence microscopy image volumes, achieving denoising and resolution improvements across multiple microscopy techniques.

Nature Methods · May 31, 2021Peer-reviewedBioengineering

Potent neutralization antibodies induced by a recombinant trimeric Spike protein vaccine candidate containing PIKA adjuvant for COVID-19

J. Tong, C. Zhu, H. Lai, C. Feng, D. Zhou

This study evaluates a recombinant trimeric Spike protein vaccine with PIKA adjuvant, showing high neutralizing antibody titers and efficacy against COVID-19.

bioRxiv · Feb 17, 2021Immunology

Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer

B. Dong, J. Miao, Y. Wang, W. Luo, Z. Ji, H. Lai, M. Zhang, X. Cheng, J. Wang, Y. Fang, H. H. Zhu, C. W. Chua, L. Fan, Y. Zhu, J. Pan, , W. Q. Gao

The paper uses single-cell RNA sequencing to show neuroendocrine prostate cancer cells originate from luminal-like cells, not basal cells, and identifies associated gene signatures.

bioRxiv · May 12, 2020Cancer Biology

A hybrid open-top light-sheet microscope for multi-scale imaging of cleared tissues

A. K. Glaser, K. W. Bishop, L. A. Barner, E. A. Susaki, S. I. Kubota, G. Gao, R. B. Serafin, P. Balaram, E. Turschak, P. R. Nicovich, H. Lai, L. A. G. Lucas, Y. Yi, E. K. Nichols, H. Huang, , J. T. C. Liu

The paper introduces a hybrid light-sheet microscope that enables versatile multi-scale imaging of cleared tissues with varying resolution, geometry, and compatibility requirements.

bioRxiv · May 6, 2020Bioengineering