Author

A. B. McDermott

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 9 Assay:proteomics· 5 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2

Frequent Co-Authors

M. Kanekiyo· 6 shared B. S. Graham· 5 shared R. A. Gillespie· 5 shared S. F. Andrews· 5 shared Y. Tsybovsky· 4 shared A. Creanga· 3 shared J. R. Mascola· 3 shared K. S. Corbett· 3 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

M. Kanekiyo

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Immune memory shapes human polyclonal antibody responses to H2N2 vaccination

Y. R. Yang, J. Han, H. R. Perrett, S. T. Richey, A. M. Jackson, A. J. Rodriguez, R. A. Gillespie, S. O'Connell, J. E. Raab, L. Y. Cominsky, A. Chopde, M. Kanekiyo, K. V. Houser, G. L. Chen, A. B. McDermott, , A. B. Ward

This study examines how prior H2 influenza exposure influences polyclonal antibody responses to H2N2 vaccination, showing differences in epitope targeting between H2-exposed and H2-naive individuals.

bioRxiv · Aug 23, 2023Immunology

C1q Enables Influenza HA Stem Binding Antibodies to Block Viral Attachment and Broadens the Antibody Escape Repertoire

I. Kosik, J. D. S. Santos, M. Angel, Z. Hu, J. Holly, J. S. Gibbs, T. U. Gill, M. Kosikova, T. Li, W. Bakhache, P. T. Dolan, H. Xie, S. F. Andrews, R. A. Gillespie, M. Kanekiyo, , j. yewdell

This study shows that C1q enhances anti-hemagglutinin stem antibody neutralization by blocking viral attachment and expanding the viral escape repertoire.

bioRxiv · Jun 12, 2023 · PreprintMicrobiology

Vaccine-elicitation of cross-group neutralizing protective antibodies to influenza A viruses

S. M. Moin, J. C. Boyington, S. Boyoglu-Barnum, R. A. Gillespie, G. Cerutti, C. S.-F. Cheung, A. Cagigi, J. R. Gallagher, J. Brand, M. Prabhakaran, Y. Tsybovsky, T. Stephens, B. E. Fisher, A. Creanga, S. Ataca, , M. Kanekiyo

This study shows that co-immunization with stem immunogens from group 1 and 2 influenza A HAs elicits cross-group neutralizing antibodies and protective immunity in multiple animal models.

bioRxiv · Feb 11, 2022 · PreprintImmunology

Variant SARS-CoV-2 mRNA vaccines confer broad neutralization as primary or booster series in mice

K. Wu, A. Choi, M. Koch, S. Elbashir, L. Ma, D. Lee, A. Woods, C. Henry, C. Palandjian, A. Hill, H. Jani, J. Quinones, N. Nunna, S. O'Connell, A. B. McDermott, , D. K. Edwards

This study evaluates updated SARS-CoV-2 mRNA vaccines in mice, showing that mRNA-1273.351 boosts neutralization against B.1.351 and mRNA-1273.211 provides broad cross-variant protection.

bioRxiv · Apr 13, 2021Microbiology

Antibodies with potent and broad neutralizing activity against antigenically diverse and highly transmissible SARS-CoV-2 variants

L. Wang, T. Zhou, Y. Zhang, E. S. Yang, C. A. Schramm, W. Shi, A. Pegu, O. K. Oloninyi, A. Ransier, S. Darko, S. R. Narpala, C. Hatcher, D. R. Martinez, Y. Tsybovsky, E. Phung, , Mascol

The paper identifies ultrapotent antibodies from convalescent donors that neutralize SARS-CoV-2 variants and reduce escape mutant generation.

bioRxiv · Feb 25, 2021Immunology

Using Neutralization Landscapes to enumerate Antibody Behavior and Decompose Antibody Mixtures

T. Einav, A. Creanga, S. F. Andrews, A. B. McDermott, M. Kanekiyo

The paper introduces a Neutralization Landscape to analyze antibody-virus interactions and decompose antibody mixtures targeting influenza hemagglutinin stem proteins.

bioRxiv · Aug 28, 2020Immunology

Plasmodium falciparum-specific IgM B cells dominate in children, expand with malaria and produce parasite inhibitory IgM

C. Hopp, A. Diouf, K. Miura, K. Boswell, P. Sekar, J. Skinner, C. M. Tipton, M. Chambers, S. Andrews, J. Tan, S. Li, S. Doumbo, K. Kayentao, A. Ongoiba, B. Traore, , P. D. Crompton

The paper identifies Pf-specific IgM B cells in children, showing they expand during malaria and produce inhibitory IgM antibodies.

bioRxiv · Apr 12, 2020Immunology

A comprehensive influenza reporter virus panel for high-throughput deep profiling of neutralizing antibodies

A. Creanga, R. A. Gillespie, B. E. Fisher, S. F. Andrews, L. Hatch, T. Stephens, Y. Tsybovsky, M. C. Crank, A. B. McDermott, J. R. Mascola, B. S. Graham, M. Kanekiyo

The paper develops a fluorescent reporter virus panel to enable high-throughput neutralization profiling of influenza antibodies without requiring high-containment labs.

bioRxiv · Feb 24, 2020Immunology

Design of nanoparticulate group 2 influenza hemagglutinin stem antigens that activate unmutated ancestor B cell receptors of broadly neutralizing antibody lineages

K. S. Corbett, S. M. Moin, H. M. Yassine, A. Cagigi, M. Kanekiyo, S. Boyoglu-Barnum, S. I. Myers, Y. Tsybovsky, A. K. Wheatley, C. A. Schramm, R. A. Gillespie, W. Shi, L. Wang, Y. Zhang, S. F. Andrews, , J. C. Boyington

This study designs nanoparticle-based influenza HA stem antigens that activate unmutated B cell receptors of broadly neutralizing antibodies, potentially enabling cross-group immunity.

bioRxiv · Dec 17, 2018Immunology

Outflanking Immunodominance to Target Subdominant Broadly Neutralizing Epitopes

D. Angeletti, I. Kosik, W. T. Yewdell, C. M. Boudreau, V. V. Mallajosyula, M. Chambers, M. Prabhakaran, H. D. Hickman, A. B. McDermott, G. Alter, J. Chaudhuri, J. W. Yewdell

This study shows that immunodominance in influenza HA can be overcome by targeting the conserved stem through specific immunization strategies.

bioRxiv · Jun 14, 2018Immunology