L. Chen

This study uses CRISPR-Cas9 to efficiently edit the Magnetospirillum magneticum AMB-1 genome, revealing Amb0994's role in magnetotactic behavior through flagellar control.

The paper develops a platform to infer and validate signaling interactions at cellular resolution during C. elegans embryogenesis, identifying Notch interactions and their role in breaking fate symmetry.

The paper presents three cryo-EM structures of pancreatic KATP channels, revealing drug binding sites, subunit interactions, and conformational changes related to metabolic regulation.

The paper uses machine learning to show that short DNA sequence patterns predictive of enhancers are conserved across mammals, while more complex patterns show greater divergence.

This study shows that diet modifies the microbiota and CD4+ T cell repertoire in a mouse model of IL-23-induced colitis, leading to disease flares.

This study identifies tetracyclines as targeting human rRNA substructures, modifying translation and activating the ISR, which correlates with their anti-proliferative effects in cancer cells.

This study uses whole-genome sequencing of 76 Magnaporthe oryzae isolates to analyze population structure and gene flow, revealing multiple divergent lineages and evidence of inter-lineage genetic exchange.

The paper identifies transcriptomes of major renal collecting-duct cell types in mice using single-cell RNA-Seq and creates an online gene-expression database.

The paper identifies DA1 as a ubiquitin-activated peptidase in Arabidopsis that cleaves and destabilizes E3 ligases and growth regulatory proteins to limit cell proliferation during organ development.