L. Chen

This study identifies GATA3 and AP1-driven enhancer reprogramming as a mechanism promoting phenotypic plasticity and endocrine resistance in breast cancer.

The paper uses QTL mapping to show MHC variants bias TRBV gene usage in UCB samples, revealing germline-encoded TCR-MHC contacts influence TCR repertoire.

This study shows that the insulin-like signaling pathway influences uric acid metabolism in Drosophila, with conserved effects in humans, and identifies potential therapeutic targets for gout and kidney stones.

This study reports cryo-EM structures of human sGC 1β1 heterodimer in different states, revealing the structural mechanism of NO-induced activation.

This study shows that Crif1 promotes radiation-induced osteoporosis in mice by increasing RANKL expression and that targeting Crif1 could be a therapeutic strategy.

This study identifies FACT as a factor that influences Cas9 turnover and genome editing efficiency in human cells.

This study shows that CD8+ T-cells mediate immunoediting in murine gliomas, affecting genomic stability and immune evasion.

The paper predicts and validates common neoantigens in colorectal cancer that are both presented and immunogenic, identifying potential universal targets for immunotherapy.

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

This study develops a proteomic workflow for FFPE tissues to stratify prostate cancer and DLBCL samples, identifying MPO as a prognostic marker and showing FFPE's utility for biomarker discovery.

The paper identifies G-quadruplexes as insulators that up-regulate X chromosome regions in Drosophila males through dosage compensation.

This study shows HIV-associated extracellular vesicles enhance KSHV infectivity in oral epithelial cells via TAR RNA and EGFR, suggesting EGFR inhibition as a potential therapeutic strategy.

This paper introduces a sonogenetic method using an engineered auditory-sensing protein to control cellular activities with ultrasound, showing it can stimulate neurons in deep brain regions non-invasively.

This paper introduces a point-of-care NMR system to assess oxidative stress in diabetes patients, enabling rapid sub-stratification based on redox status and glycemic levels.

This paper investigates how Prototheca zopfii genotype II causes mitochondrial apoptosis and inflammation in bovine mastitis models.

This study examines C4d deposition in renal tissues of primary Sjögren's syndrome patients, finding higher serum creatinine levels in those with tubulointerstitial C4d positivity.

This study shows amino sugars like GlcNAc and GlcN enhance the competitiveness of commensal oral streptococci against S. mutans, reducing its viability in co-cultures and biofilms.

This study identifies NADP+ and NADPH as substrates of the circadian protein Nocturnin, showing its enzymatic activity in converting these metabolites and revealing structural insights into its mechanism.

This study identifies and characterizes a novel pic gene cluster in Alcaligenes faecalis JQ135 responsible for complete picolinic acid degradation into the tricarboxylic acid cycle.

This study investigates how rFIP-glu modulates macrophage immune responses via distinct signaling pathways, showing its potential therapeutic applications.

This study demonstrates that tungsten oxide nanodots exhibit strong antibacterial activity against both gram-negative and gram-positive bacteria, with enhanced efficacy under sunlight exposure and confirmed biocompatibility.

This study compares the venom effectiveness of fire ant queens and workers, finding queen venoms act faster to knock down competitors than worker venoms.

This study identifies circZKSCAN1 as a negative regulator of cancer stem cells in hepatocellular carcinoma, revealing its mechanism through interaction with FMRP and CCAR1-Wnt signaling.

This paper introduces Hessian-SMLM, a method to reduce pixel-dependent readout noise in sCMOS cameras for single-molecule localization microscopy, improving imaging time resolution.

This paper introduces a tumor-specific causal inference framework to identify causative somatic genome alterations and their impact on molecular phenotypes in individual tumors.

The paper shows MTAP loss in GBM correlates with an immunosuppressive profile by increasing M2 macrophages and that MTA, a byproduct of MTAP loss, promotes this effect through the A2B receptor.

This study identifies extracellular HBV RNAs as heterogeneous in length, present in virions and capsid-antibody-complexes in CHB patients, and capable of serving as templates for viral DNA synthesis.

This study evaluates the GenoType MTBDRplus and MTBDRsl assays for detecting drug-resistant Mycobacterium tuberculosis in Beijing isolates, showing high sensitivity for rifampicin and INH resistance, and their potential as supplementary diagnostic tools.

The paper presents the structure of human TRPC6 ion channel in complex with inhibitor BTDM, revealing its architecture and inhibition mechanism.

This study shows that IL-33 regulates gene expression in intestinal epithelial cells through its extracellular form, not its nuclear form, by using transgenic mice and ST2-deficient mice.