F. Su

Silybin A from Silybum marianum reprograms lipid metabolism to induce a cell fate-dependent class switch from triglycerides to phospholipids

This study identifies silybin A's role in reprogramming lipid metabolism to shift from triglycerides to phospholipids in liver cells, with implications for liver protection.

p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer

This study shows that degrading p300/CBP in prostate cancer suppresses tumor growth more effectively than inhibiting their activity, highlighting their role in maintaining the active AR enhanceosome.

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer

This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.

PIKfyve controls dendritic cell function and tumor immunity

This study shows that PIKfyve inhibition enhances dendritic cell function and improves immunotherapy efficacy in tumor models.

Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies

This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.

Clonal hematopoiesis detection in cancer patients using cell free DNA sequencing

The paper trains a machine learning model to detect clonal hematopoiesis in cancer patients using cell-free DNA sequencing and characterizes associated tumor microenvironment changes.

Deep learning identifies pathological abnormalities predictive of graft loss in kidney transplant biopsies

This paper develops a deep learning model to quantify pathological features in kidney transplant biopsies, showing improved prediction of graft loss compared to clinical and Banff scores.

A cold shock protein from a thermophile bacterium promotes the high-temperature growth of bacteria and fungi through binding to diverse RNA species

Lipidomic profiling of plasma extracellular vesicles as an effective means to evaluate the risk of preterm birth

This study identifies lipid differences in plasma, microvesicles, and exosomes between preterm and full-term pregnancies, finding microvesicle lipids better predict preterm birth risk.

Pan-genome analysis reveals the molecular basis of niche adaptation of Staphylococcus epidermidis strains

This study analyzes the pan-genome of Staphylococcus epidermidis to identify genomic factors associated with its adaptation to diverse niches and pathogenicity.

Virus infection might cause cells producing black swimming dots

The paper investigates a virus-like pathogen associated with black swimming dots (BSDs) in cultured cells, showing it can be reisolated from BSD+ extracts-inoculated cells.

Black swimming dots in cell culture: the identity, detection method and judging criteria

The paper investigates the origin, detection, and criteria for identifying black swimming dots (BSDs) in cell culture, addressing their nature and impact on experiments.