P. Sharma

This study uses molecular dynamics simulations to analyze the translocation mechanism of the antimicrobial peptide CM15 across the outer membrane of E. coli, revealing key structural and energetic features of the process.

This study uses molecular dynamics simulations to examine nanoparticle translocation through skin lipid membranes, finding coated nanoparticles more efficiently traverse double bilayer models than bare particles.

The paper identifies Avobenzone, Guaiazulene, and Tioxolone as potent autophagy inducers through a high-throughput image-based screen using a GFP-LC3-RFP reporter system in A375 cells.

This study identifies RICTOR's role in regulating ganglioside biosynthesis via ZFX and UGCG, promoting breast cancer progression through EGFR signaling.

This study compares the severity of SARS-CoV-2 Omicron-B.1.1.529, Pango B, and Delta variants in a mouse model, finding Omicron causes less severe disease with lower viral load and inflammation.

This paper demonstrates that a multimerised SARS-CoV-2 RBD vaccine using a stable scaffold provides enhanced antibody responses and complete protection in mice.

This study shows that non-stimulatory cargo-free particles enhance phagocytic ability in macrophages and neutrophils, leading to faster bacterial clearance.

This study shows that keratin 19 interacts with GSK3β to inhibit its nuclear accumulation and prevent cyclin D3 degradation, affecting cell proliferation and CDK4/6 inhibitor sensitivity.

This study shows that Pten downregulation is essential for zebrafish retina regeneration by promoting Muller glia-derived progenitor cell proliferation through Akt and Mmp9/Notch pathways.

This study evaluates MARTINI force-fields for simulating the ripple phase of lipid membranes, finding that they fail to capture the phase at larger system sizes due to kinetic trapping and require re-parametrization.

This paper demonstrates the use of induced pluripotent stem cells to create an isogenic system for studying genetic influences on cell-cell interactions in type 1 diabetes.

This study investigates SARS-CoV-2 variant neuroinvasion in K18-hACE2 mice, finding CNS spread in all variants except Omicron, with microglial activation and immune cell apoptosis observed.

This study characterizes plasmablasts in dengue patients from India, showing their transcriptional features, adhesion molecule expression, and differential expansion based on infection severity.

The paper tests if rain is a reservoir of tomato phyllosphere microbiota by comparing microbial communities on rain-exposed and protected tomato leaves.

This study shows that immune cells can phagocytose polymeric particles under flow conditions, similar to or better than static conditions, with implications for particle design.

This study shows that prior SARS-CoV-2 infection in Syrian Golden Hamsters protects against re-exposure to variants B.1.1.7 and B.1.351, suggesting immunity may limit disease from emerging variants.

This study shows endothelial alpha globin functions as a nitrite reductase to mediate hypoxia-induced vasodilation in resistance arteries.

This study examines how breast cancer tumors evolve during early stage treatment with combination CDK and endocrine inhibitors, finding convergent resistance pathways and increased subclonal diversity with combination therapy.

The paper introduces an ICDC approach to identify distal mutations that modulate protein function through dynamic allostery, validated on TEM-1 β-lactamase and applied to Cyanovirin-N.

This study shows that artificial selection in Drosophila melanogaster led to early chronotypes with enhanced masking and advanced entrainment phases, suggesting masking contributes to circadian phasing.

This study shows that sequential infection with influenza A virus followed by SARS-CoV-2 in mice leads to more severe disease and encephalitis compared to single infections.

This study shows that the gut microbiome influences brain function and metabolic changes in mosquitoes through a microbiome-gut-brain axis.

This study demonstrates direct shoot regeneration from cotyledons, leaves, and roots of Citrus jambhiri using tissue culture techniques, with varying success rates and plantlet health outcomes.

This study analyzes single-cell RNA and TCR profiles from AML patients before and after PD-1 blockade therapy to identify factors influencing response and resistance.

The paper analyzes SARS-CoV-2 genomic data from India to trace introduction and local transmission, identifying multiple clades and highlighting the need for molecular surveillance.

This paper develops a coarse-grained MARTINI model for peptidoglycan and evaluates its mechanical properties and free energy barriers for small molecule insertion.

This study evaluates the antiviral activity of heparin and enoxaparin derivatives against SARS-CoV-2 by testing their ability to neutralize pseudotyped virus particles.

This study shows that keratin 19 maintains E-cadherin at the cell surface, stabilizes cell-cell adhesion, and influences migration and colony formation in MCF7 cells.

This study shows that non-canonical autophagy, mediated by the WD and linker domains of ATG16L1, protects against lethal influenza A virus infection by limiting viral replication and inflammation in airway epithelial cells.

The paper tests metagenomic sequencing with ONT MinION for strain-level identification of bacterial tomato pathogens, achieving success with Pto but showing challenges with field samples.