A. Bell

Exploring the PET in vivo generator 134Ce as a theranostic match for 225Ac

This paper compares 225Ac and 134Ce-labeled tracers in cancer models to assess their suitability as a theranostic pair, finding that 134Ce's PET imaging is limited by daughter nuclide redistribution.

Characterisation of anhydro-sialic acid transporters from mucosa-associated bacteria

The paper identifies and characterizes anhydro-sialic acid transporters in bacteria, showing their specific or promiscuous substrate preferences.

A spatial atlas of Wnt and Frizzled receptor expression in adult mouse liver

The paper maps the spatial expression of Wnt and Frizzled receptors in adult mouse liver, revealing zonation patterns and cell-type-specific expression.

Long-read powered viral metagenomics in the oligotrophic Sargasso Sea

This study uses long-read sequencing to analyze viral communities in the Sargasso Sea, identifying new phage populations and highlighting the importance of long reads for viral genome diversity and function.

Dynamic control of metabolic zonation and liver repair by endothelial cell Wnt2 and Wnt9b revealed by single cell spatial transcriptomics using Molecular Cartography

This study identifies endothelial cell Wnt2 and Wnt9b as key regulators of liver zonation and repair, showing their therapeutic potential in acute liver failure using single-cell spatial transcriptomics.

β-Catenin-NFκB-CFTR interactions in cholangiocytes regulate inflammation and fibrosis during ductular reaction

This study identifies a β-catenin-NFκB-CFTR interactome in cholangiocytes that regulates inflammation and fibrosis during ductular reaction in liver disease.

Multiple evolutionary origins reflect the importance of sialic acid transporters in the colonisation potential of bacterial pathogens and commensals.

This study identifies multiple evolutionary origins of sialic acid transporters in bacteria, highlighting their role in host-microbe interactions and microbial colonization.

A behavioral syndrome linking boldness and flexibility facilitates invasion success in sticklebacks

This study links boldness and flexibility in sticklebacks to invasion success, showing these traits are negatively correlated and evolutionarily divergent.

NOTCH-YAP1/TEAD-DNMT1 axis regulates hepatocytereprogramming into intrahepatic cholangiocarcinoma

The paper identifies a NOTCH-YAP1/TEAD-DNMT1 axis that drives hepatocyte reprogramming into intrahepatic cholangiocarcinoma and reveals its role in tumor development.

Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors

This study shows YAP1 is essential for bile duct development and reveals hepatocyte adaptation in its absence.

Personality traits change after an opportunity to mate

The paper shows that mating and courtship experiences in female threespine sticklebacks reduce risk-taking and sociability, linked to increased dihydroxyprogesterone levels.

The life of P.I. - Transitions to Independence in Academia

This report analyzes data from 365 UK-based principle investigators to identify challenges in transitioning to academic independence and suggests policy and support improvements.

Enabling Precision Medicine via standard communication of NGS provenance, analysis, and results

The paper introduces the BioCompute framework to standardize genomic data reporting, enabling reproducibility and interoperability in precision medicine.

Curated compendium of human transcriptional biomarker data

The paper curates and standardizes 45 transcriptional biomarker datasets to improve data reuse for validating gene-level findings and benchmarking machine learning models.