Author

D. Qu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Immunology· 3 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 8 Organism:mouse· 5 Organism:human· 4 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2

Frequent Co-Authors

Y. Xie· 9 shared W. Xu· 7 shared X. Cai· 7 shared Y. Wu· 7 shared Y. Wang· 6 shared C. Gu· 5 shared Z. Yuan· 5 shared J. Wang· 4 shared

Activity by Year

2018-2021 · peak 7/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

9 shared papersMicrobiology

Y. Xie

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Interaction network of SARS-CoV-2 with host receptome through spike protein

Y. Gu, J. Cao, X. Zhang, H. Gao, Y. Wang, J. Wang, J. Zhang, G. Shen, X. Jiang, J. Yang, X. Zheng, J. Xu, C. C. Zhang, F. Lan, D. Qu, , Z. Lu

This study identifies multiple SARS-CoV-2 receptors, including ASGR1 and KREMEN1, which enable virus entry and correlate with multi-organ tropism and clinical symptoms.

Cell Research · Nov 26, 2021Peer-reviewedMicrobiology

Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

T. Li, X. Han, C. Gu, H. Guo, H. Zhang, Y. Wang, C. Hu, K. Wang, F. Liu, F. Luo, Y. Zhang, J. Hu, W. wang, S. Li, Y. Hao, , A. Jin

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

bioRxiv · Apr 19, 2021Immunology

A key linear epitope for a potent neutralizing antibody to SARS-CoV-2 S-RBD

T. Li, X. Han, Y. Wang, C. Gu, J. Wang, C. Hu, S. Li, K. Wang, F. Luo, J. Huang, Y. Long, S. Song, W. Wang, J. Hu, R. Wu, , A. Jin

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

bioRxiv · Sep 11, 2020 · PreprintImmunology

Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide

D. Gao, F. Li, M. Han, P. Dai, W. Xu, J. He, X. Tao, Y. Wu, X. Tong, X. Xia, W. Guo, Y. Li, Y. Zhu, X. Zhang, Z. Liu, , Y. Zhou

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

bioRxiv · Sep 11, 2020Microbiology

Engineered Trimeric ACE2 Binds and Locks "Three-up" Spike Protein to Potently Inhibit SARS-CoVs and Mutants

L. Guo, W. Bi, X. Wang, W. Xu, R. Yan, Y. Zhang, K. Zhao, Y. Li, M. Zhang, X. Bao, X. Cai, Y. Li, D. Qu, S. Jiang, Y. Xie, , B. Dang

This study engineers a trimeric ACE2 protein that binds the spike protein with high affinity, inhibiting SARS-CoVs and mutants by locking the spike in a 'three-up' conformation.

bioRxiv · Aug 31, 2020Bioengineering

The S1/S2 boundary of SARS-CoV-2 spike protein modulates cell entry pathways and transmission

Y. Zhu, F. Feng, G. Hu, Y. Wang, Y. Yu, Y. Zhu, W. Xu, X. Cai, Z. Sun, W. Han, R. Ye, H. Chen, Q. Ding, Q. Cai, D. Qu, , R. Zhang

This study shows that the S1/S2 boundary of the SARS-CoV-2 spike protein affects cell entry and transmission by altering the pathway used for viral entry.

bioRxiv · Aug 25, 2020Microbiology

A rapid and efficient screening system for neutralizing antibodies and its application for the discovery of potent neutralizing antibodies to SARS-CoV-2 S-RBD

X. Han, Y. Wang, S. Li, C. Hu, T. Li, C. Gu, K. Wang, M. Shen, J. Wang, J. Hu, R. Wu, S. Mu, F. Gong, Q. Chen, F. Gao, , A. Jin

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

bioRxiv · Aug 19, 2020Immunology

Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement

J. Zang, C. Gu, B. Zhou, C. Zhang, Y. Yang, S. Xu, X. Zhang, Y. Zhou, L. Bai, Y. Wu, Z. Sun, R. Zhang, Q. Deng, Z. Yuan, H. Tang, , Z. Huang

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

bioRxiv · May 21, 2020Microbiology

Protoporphyrin IX and verteporfin prevent SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2

C. Gu, Y. Wu, H. Guo, Y. Zhu, W. Xu, Y. Wang, Y. Zhou, Z. Sun, X. Cai, Y. Li, J. Liu, Z. Huang, Z. Yuan, R. Zhang, Q. Deng, , Y. Xie

This study shows that protoporphyrin IX and verteporfin inhibit SARS-CoV-2 infection in vitro and in a human ACE2-expressing mouse model by blocking ACE2-S protein interaction.

bioRxiv · Apr 30, 2020 · PreprintMicrobiology

Nilotinib activates endothelial TLR4 to exacerbate atherosclerosis

D. Qu, M. Huo, L. Wang, C.-W. Lau, X. Y. Tian, Y. Huang

This study shows nilotinib activates endothelial TLR4, promoting atherosclerosis, and suggests TLR4 inhibition could mitigate this effect.

bioRxiv · Dec 14, 2019 · PreprintCell Biology

In Vitro Activities of Daptomycin Combined with Fosfomycin or Rifampin on Planktonic and Adherent Linezolid-resistant Enterococcus faecalis

J.-x. Zheng, S. Xiang, Z.-w. Lin, G.-b. Qi, H.-p. Tu, Y. Wu, S.-b. Jiang, z. chen, Q. Deng, D. Qu, Z.-j. Yu

This study evaluates the effectiveness of daptomycin combined with fosfomycin or rifampin against linezolid-resistant Enterococcus faecalis biofilms and planktonic cells.

bioRxiv · Jun 14, 2018Microbiology