S. Dutta

This study investigates how PDZ domains in HtrA2 subunits synergistically regulate allosteric activation through inter-subunit crosstalk, revealing a model of cooperative energy landscape dynamics.

This study examines how tectonic and climatic changes during the Oligo-Miocene affected bivalve fauna in the Kutch Basin, finding limited faunal exchange and stable diversity patterns.

This study shows that rotenone treatment causes early NAD+ loss, leading to Sarm1 activation, which is prevented by PARP inhibition in both cell cultures and Drosophila.

This study examines how co-infections with Plasmodium falciparum and helminths affect antibody responses in Mozambican individuals, finding increased IgE and IgG levels in co-infected individuals.

This study investigates the molecular mechanism of partial agonism in cannabinoid receptors, finding that THC stabilizes both agonist and antagonist-like poses through its alkyl side chain, leading to partial receptor activation.

This study examines how past logging and ongoing anthropogenic disturbances affect vegetation in Himalayan Foothills, finding that selective logging promotes secondary forest features but CAD reduces native diversity and facilitates invasions.

This study uses molecular dynamics simulations to investigate Na+ binding mechanisms in cannabinoid receptors CB1 and CB2, identifying distinct binding sites and pathways.

This study compares the immunogenicity of soluble trimeric influenza stem domain immunogens and nanoparticle-displayed versions, showing similar protection against homologous and heterologous viral challenges.

This study investigates the hypoglycaemic effect of Manilkara hexandra leaf extract on glucose metabolism in Labeo rohita fingerlings by analyzing enzyme activities and serum glucose levels.

This study designs a thermotolerant trimeric RBD vaccine candidate that elicits strong neutralizing antibodies against multiple SARS-CoV-2 variants in animal models.

This study examines how land-use changes affect bird communities in the Western Thar Desert, finding that protected grasslands support higher bird diversity and specialists, while croplands and rangelands negatively impact specialists.

This study identifies Hmrhl as a regulator of cancer-related genes in CML through chromatin association and functional experiments.

This paper designs a thermotolerant, immunogenic SARS-CoV-2 RBD protein fragment that is stable at high temperatures and elicits neutralizing antibodies in guinea pigs.

This study analyzes SARS-CoV-2 genomic diversity in India, identifying 33 mutations and classifying strains into 22 groups based on co-existing mutations.

The paper shows that bromelain peptides from pineapple inhibit Aβ fibrillation and dissociate preformed fibrils, reducing their cytotoxicity in cells and animal models.

This paper demonstrates magnetoelectric materials enable miniature, wireless neural stimulators operating at therapeutic high-frequencies for treating Parkinson's disease in rodents.

This study shows that Atf-6 extends lifespan in C. elegans by modulating ER-mitochondrial calcium homeostasis and signaling.

The paper identifies structural differences between β-arrestin isoforms using conformational sensors and domain-swapping, linking these differences to their distinct functional outcomes in GPCR signaling.

The paper identifies alpha-Synuclein as a target of HYPE-mediated adenylylation, showing it reduces Syn aggregation and ER stress in Parkinson’s disease models.

This study isolates and characterizes an HIV-1 broadly neutralizing antibody from a pediatric elite neutralizer, showing potent neutralization of cross-clade and autologous viruses.

The paper introduces a mechanical framework linking protein sequence, dynamics, and function through the Green function, showing how epistasis arises from nonlinearity in force propagation.

This study identifies TRIP6 as a mechanotransduction component that inhibits Hippo signaling by blocking LATS1/2 activation in response to tension at adherens junctions.

This paper introduces a method to synchronize flagellar length in Chlamydomonas reinhardtii without cell cycle synchronization, enabling precise study of flagellar regulation.