Author

U. Guha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Pathology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 8 Organism:human· 7 Approach:experimental assay· 6 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:metabolomics· 2 Organism:mouse· 2

Frequent Co-Authors

X. Zhang· 5 shared S. Gao· 4 shared C. M. Cultraro· 3 shared K. D. Nguyen· 3 shared T. K. Maity· 3 shared A. Venugopalan· 2 shared A. Z. Rosenberg· 2 shared B. A. Jones· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersCancer Biology

X. Zhang

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

P. A. Desai, N. Takahashi, R. Kumar, S. Nichols, J. Malin, A. Hunt, C. Schultz, Y. Cao, D. Tillo, D. Nousome, L. Chauhan, L. Sciuto, K. Jordan, V. Rajapakse, D. Lissa, , R. El Meskini

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

bioRxiv · Feb 9, 2024Cancer Biology

Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney

X. X. Wang, K. Myakala, A. E. Libby, S. Ranjit, S. Takahashi, B. A. Jones, K. Bhasin, Y. Qi, K. Krausz, P. Zerfas, J. Panov, t. J. velenosi, d. P. patel, P. Daneshpajouhnejad, A. Titievsky, , M. Levi

This study shows that ERR agonism improves mitochondrial function and reduces inflammation in aging kidneys, while STING inhibition also reduces inflammation and increases mitochondrial gene expression.

The American Journal of Pathology · Dec 1, 2023Peer-reviewedPathology

NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease

K. Myakala, X. Wang, N. V. Shults, B. A. Jones, X. Yang, A. Z. Rosenberg, B. Ginley, P. Sarder, L. Brodsky, Y. Jang, C. H. Na, Y. Chi, X. Zhang, U. Guha, C. Wu, , M. Levi

This study shows that nicotinamide riboside (NR) improves mitochondrial function and reduces inflammation in diabetic kidney disease by enhancing NAD metabolism and inhibiting the cGAS-STING pathway.

bioRxiv · Dec 5, 2021Pathology

A novel small molecule that induces cytotoxicity in lung cancer cells inhibits disulfide reductases GSR and TXNRD1

F. D. Johnson, J. Ferrarone, A. Liu, C. Brandstadter, R. Munuganti, D. Fansworth, D. Lu, J. Luu, T. Sihota, S. Jansen, A. Nagelberg, R. Shi, G. C. Forcina, X. Zhang, G. S. W. Cheng, , W. W. Lockwood

The paper identifies LCS3, a compound that induces oxidative stress in lung cancer cells by inhibiting disulfide reductases GSR and TXNRD1, and shows its synergistic effect with glutathione and thioredoxin pathway inhibition.

bioRxiv · Jun 28, 2021 · PreprintCancer Biology

Proteogenomic analysis unveils the HLA Class I presented immunopeptidome in melanoma and EGFR mutant lung adenocarcinoma

Y. A. Qi, T. K. Maity, C. M. Cultraro, V. Misra, X. Zhang, C. Ade, S. Gao, D. Milewski, K. D. Nguyen, M. H. Ebrahimabadi, K.-i. Hanada, J. Khan, C. Sahinalp, J. C. Yang, U. Guha

The paper identifies HLA Class I-presented peptides in melanoma and EGFR mutant lung adenocarcinoma using proteogenomic analysis, revealing neopeptides and post-translationally modified peptides for potential immunotherapy.

bioRxiv · Aug 4, 2020Immunology

Global proteome and phosphoproteome alterations in third generation EGFR TKI resistance reveal drug targets to circumvent resistance

X. Zhang, T. Maity, K. Ross, Y. Qi, C. Cultraro, S. Gao, K. D. Nguyen, J. Cowart, F. Kirkali, C. Wu, U. Guha

The paper analyzes proteome and phosphoproteome changes in EGFR TKI-resistant lung cancer cells to identify drug targets that can overcome resistance.

bioRxiv · Jul 4, 2020Cancer Biology

Quantitative mass spectrometry to interrogate proteomic heterogeneity in metastatic lung adenocarcinoma and validate a novel somatic mutation CDK12-G879V

X. Zhang, K. D. Nguyen, P. Rudnick, N. Roper, E. Kawaler, T. K. Maity, S. Awasthi, S. Gao, R. Biswas, A. Venugopalan, C. M. Cultraro, D. Fenyo, U. Guha

The paper uses quantitative mass spectrometry to analyze proteomic and phosphoproteomic changes in metastatic lung adenocarcinoma and validates a novel somatic mutation CDK12-G879V associated with chemotherapy sensitivity.

bioRxiv · Aug 22, 2018Cancer Biology

Integrated proteogenomic analysis of metastatic thoracic tumors identifies APOBEC mutagenesis and copy number alterations as drivers of proteogenomic tumor evolution and heterogeneity

N. Roper, S. Gao, T. K. Maity, A. R. Banday, X. Zhang, A. Venugopalan, C. M. Cultraro, R. Patidar, S. Sindiri, A. Goncearenco, A. R. Panchenko, R. Biswas, A. Thomas, A. Rajan, C. A. Carter, , U. Guha

bioRxiv · May 11, 2018Cancer Biology