Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stresses
J. Wang, Y. Wen, W. Zhao, Y. Zhang, F. Lin, C. Ouyang, H. Wang, L. Yao, H. Ma, Y. Zhuo, H. Huang, X. Shi, L. Feng, D. Lin, B. Jiang, Q. Li
The paper identifies acetate as a novel energy stress marker produced in the liver via ACOT12/8-mediated conversion of acetyl-CoA from fatty acids, supporting its role in brain fueling and CoA recycling.
bioRxiv · Mar 23, 2023 · PreprintBiochemistry