M. Angelo

Epstein-Barr Virus Orchestrates Spatial Reorganization and Immunomodulation within the Classic Hodgkin Lymphoma Tumor Microenvironment

This study uses spatial multi-omics to compare EBV-positive and EBV-negative cHL, identifying distinct TME features and immunological signatures linked to EBV.

A Spatial Multi-Modal Dissection of Host-Microbiome Interactions within the Colitis Tissue Microenvironment

This study introduces MicroCart, a framework for spatial multi-omics analysis of host-microbiome interactions in colitis, revealing tissue-level immune responses and microbial shifts.

In silico {lambda}-dynamics predicts protein binding specificities to modified RNAs

This paper uses in silico λ-dynamics to predict antibody binding specificities to RNA modifications, showing high agreement with experimental results.

Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity

This study shows germline variants influence somatic evolution in breast cancer by modulating immunoediting, affecting tumor subtype and metastatic potential.

Single-Cell Imaging Maps Inflammatory Cell Subsets to Pulmonary Arterial Hypertension Vasculopathy

The paper maps immune cell subsets in PAH lungs using MIBI-TOF, identifying mo-DCs and their role in vascular remodeling and linking immune dysregulation to disease severity in HPAH.

Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted by metastasis

The paper examines CD8+ T cell responses in human lymph nodes during cancer immunotherapy and finds that metastasis disrupts these responses.

Reproducible, high-dimensional imaging in archival human tissue by Multiplexed Ion Beam Imaging by Time-of-Flight (MIBI-TOF)

This study validates MIBI-TOF for consistent, high-dimensional imaging in archival human tissue, showing high concordance with single-plex IHC and automated cell population analysis.

Virus-Dependent Immune Conditioning of Tissue Microenvironments

The paper develops PANINI-MIBI to analyze DNA, RNA, and protein in SIV-infected tissues, revealing IL10 upregulation and macrophage polarization linked to viral latency.

Multiplexed Ion Beam Imaging Readout of Single-Cell Immunoblotting

This paper introduces scIB-MIBI-TOF, a method combining single-cell immunoblotting with multiplexed ion beam imaging to detect proteoforms from glioblastoma cells.

Multiplexed Imaging Analysis of the Tumor-Immune Microenvironment Reveals Predictors of Outcome in Triple-Negative Breast Cancer

The paper uses multiplexed ion-beam imaging to analyze the tumor-immune microenvironment in triple-negative breast cancer, identifying immunological predictors of patient outcomes.

Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma

The paper analyzes tumor microenvironment changes from normal to invasive breast cancer using imaging and machine learning, finding coordinated shifts in stromal cell location and function.

Multiplexed imaging of human tuberculosis granulomas uncovers immunoregulatory features conserved across tissue and blood

This study uses multiplexed imaging and transcriptomics to identify immunosuppressive features in TB granulomas and blood, linking local and systemic immune responses.

Multiplexed Single-cell Metabolic Profiles Organize the Spectrum of Human Cytotoxic T Cells

This study maps metabolic profiles of human cytotoxic T cells using single-cell technologies, revealing tissue-specific metabolic states and spatial metabolic neighborhoods in colorectal carcinoma.