Author

A. Gautam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Immunology· 3 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 6 Assay:proteomics· 6 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:human· 4 Approach:statistical model· 4 Organism:virus· 4

Frequent Co-Authors

B. Chen· 6 shared P. Tong· 6 shared T. Xiao· 5 shared Y. Cai· 5 shared H. Peng· 4 shared H. Zhu· 4 shared J. Lu· 4 shared J. Zhang· 4 shared

Activity by Year

2021-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersBiochemistry

B. Chen

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Major Contribution of Myeloid Cells In TB specific Host Gene Signature: Revelations from Re-Analysis of Publicly Available Datasets

A. Gautam, S. K. Mohapatra, B. Pandit

The paper re-analyzes TB host gene expression datasets to identify a cellular circuit involving myeloid cells and their interaction with M. tuberculosis antigens.

bioRxiv · Sep 27, 2022 · PreprintImmunology

Prenatal arsenic exposure stymies gut butyrate production and enhances gut permeability in post natal life even in absence of arsenic deftly through miR122-Occludin pathway.

M. CHAKRABORTY, A. GAUTAM, O. DAS, A. MASID, M. BHAUMIK

This study shows prenatal arsenic exposure reduces gut butyrate production and increases permeability in mice, effects reversed by butyrate supplementation through miR122-Occludin pathway modulation.

bioRxiv · Jun 13, 2022Pharmacology & Toxicology

Structural and functional characteristics of SARS-CoV-2 Omicron subvariant BA.2 spike

J. Zhang, T. Weichun, H. Gao, C. Lavine, W. Shi, H. Peng, H. Zhu, K. Anand, M. Kosikova, H. J. Kwon, P. Tong, A. Gautam, S. Rits-Volloch, S. Wang, M. L. Mayer, , B. Chen

This study characterizes the structural, functional, and antigenic properties of SARS-CoV-2 Omicron BA.2 spike protein and compares its replication efficiency with previous variants.

bioRxiv · Apr 28, 2022 · PreprintMicrobiology

Structural and functional impact by SARS-CoV-2 Omicron spike mutations

J. Zhang, Y. Cai, C. Lavine, H. Peng, H. Zhu, K. Anand, P. Tong, A. Gautam, M. Mayer, S. Rits-Volloch, S. Wang, P. Sliz, D. Wesemann, W. Yang, M. Seaman, , B. Chen

This study examines the structural, functional, and antigenic properties of the SARS-CoV-2 Omicron spike protein, revealing its enhanced immune evasion and altered fusogenic capability due to mutations.

bioRxiv · Jan 11, 2022Biochemistry

Differential antibody dynamics to SARS-CoV-2 infection and vaccination

Y. Chen, P. Tong, N. B. Whiteman, A. S. Moghaddam, A. Zuiani, S. Habibi, A. Gautam, T. Xiao, Y. Cai, B. Chen, D. R. Wesemann

This study compares antibody durability and breadth after SARS-CoV-2 infection and vaccination, finding that infection-induced antibodies show greater long-term stability and cross-variant breadth.

bioRxiv · Sep 9, 2021Immunology

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant

J. Zhang, T. Xiao, Y. Cai, C. L. Lavine, H. Peng, H. Zhu, K. Anand, P. Tong, A. Gautam, M. L. Mayer, R. M. Walsh, S. Rits-Volloch, D. R. Wesemann, W. Yang, M. S. Seaman, , B. Chen

This study compares the structure, function, and antigenicity of the SARS-CoV-2 Delta variant's spike protein with other variants, showing its enhanced membrane fusion and transmissibility.

bioRxiv · Aug 17, 2021Biochemistry

Discovery of nanobodies against SARS-CoV-2 and an uncommon neutralizing mechanism

D. Li, T. Li, B. Zhou, Z. Luo, Y. Lai, S. Huang, Y. Zhou, A. Gautam, S. Bourgeau, S. Wang, J. Bao, J. Tan, D. Lavillette

This study isolates and characterizes two nanobodies against SARS-CoV-2 that neutralize the virus through distinct mechanisms, with one showing efficacy against the Alpha variant and reduced activity against the Beta variant.

bioRxiv · Jul 20, 2021 · PreprintBiochemistry

Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants

Y. Cai, J. Zhang, T. Xiao, C. L. Lavine, S. Rawson, H. Peng, H. Zhu, K. Anand, P. Tong, A. Gautam, S. Lu, S. Sterling, R. M. Walsh, S. Rits-Volloch, J. Lu, , B. Chen

This study reports cryo-EM structures of SARS-CoV-2 variants B.1.1.7 and B.1.351, revealing mutations that enhance infectivity and immune evasion.

bioRxiv · Apr 13, 2021Biochemistry

Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike

P. Tong, A. Gautam, I. Windsor, M. Travers, Y. Chen, N. Garcia, N. Whiteman, L. McKay, F. J. N. Lelis, S. Habibi, Y. Cai, L. J. Rennick, W. P. Duprex, K. McCarthy, C. L. Lavine, , D. R. Wesemann

The paper maps memory B cell receptors against SARS-CoV-2 spike variants, identifying 7 mAb competition groups and their epitopic regions, and shows their cross-reactivity and neutralization properties.

bioRxiv · Mar 10, 2021Immunology