Author

D. Lavillette

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 5 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Organism:human· 2 Assay:protein sequence· 1 Organism:virus· 1

Frequent Co-Authors

B. Zhou· 5 shared C. Zhang· 3 shared D. Li· 3 shared J. Zang· 3 shared S. Xu· 3 shared T. Li· 3 shared Z. Huang· 3 shared H. Cai· 2 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersBiochemistry

B. Zhou

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

An mRNA vaccine candidate for the SARS-CoV-2 Omicron variant

J. Zang, C. Zhang, Y. Yin, S. Xu, W. Qiao, D. LAVILLETTE, H. Wang, Z. Huang

This paper develops an mRNA vaccine targeting the Omicron variant's RBD, showing it induces Omicron-specific neutralizing antibodies but not against wildtype or Delta strains.

bioRxiv · Feb 7, 2022 · PreprintMicrobiology

Discovery of nanobodies against SARS-CoV-2 and an uncommon neutralizing mechanism

D. Li, T. Li, B. Zhou, Z. Luo, Y. Lai, S. Huang, Y. Zhou, A. Gautam, S. Bourgeau, S. Wang, J. Bao, J. Tan, D. Lavillette

This study isolates and characterizes two nanobodies against SARS-CoV-2 that neutralize the virus through distinct mechanisms, with one showing efficacy against the Alpha variant and reduced activity against the Beta variant.

bioRxiv · Jul 20, 2021 · PreprintBiochemistry

Efficacy of ancestral receptor-binding domain, S1 and trimeric spike protein vaccines against SARS-CoV-2 variants B.1.1.7, B.1.351, and B.1.617.1

Y. Yang, J. Zang, S. Xu, X. Zhang, S. Yuan, D. Lavillette, C. Zhang, Z. Huang

This study compares the efficacy of ancestral RBD, S1, and S-trimer vaccines against SARS-CoV-2 variants B.1.1.7, B.1.351, and B.1.617.1, finding that RBD and S-trimer induce higher neutralizing titers and maintain effectiveness against variants.

bioRxiv · Jun 2, 2021 · PreprintImmunology

A high-affinity RBD-targeting nanobody improves fusion partner's potency against SARS-CoV-2

H. Yao, H. Cai, T. Li, B. Zhou, W. Qin, D. Lavillette, D. Li

This study identifies a high-affinity nanobody that, when fused to other nanobodies, enhances their potency against SARS-CoV-2 by improving RBD binding without disrupting RBM conformation.

bioRxiv · Sep 24, 2020Biochemistry

The SARS-CoV-2 Envelope and Membrane proteins modulate maturation and retention of the Spike protein, allowing optimal formation of VLPs in presence of Nucleoprotein

B. Boson, V. Legros, B. Zhou, C. Mathieu, F.-L. Cosset, D. Lavillette, S. Denolly

This paper investigates how SARS-CoV-2 Envelope and Membrane proteins modulate Spike protein maturation and retention, showing their role in optimal VLP formation with Nucleoprotein.

bioRxiv · Aug 24, 2020Microbiology

A potent synthetic nanobody targets RBD and protects mice from SARS-CoV-2 infection

D. Li, T. Li, H. Cai, H. Yao, B. Zhou, Y. Zhao, W. Qin, C. A. J. Hutter, Y. Lai, J. Bao, J. Lan, G. Wong, M. Seeger, D. Lavillette, N. Zhang, , Y. Bi

bioRxiv · Jun 9, 2020 · PreprintBiochemistry

Immunization with the receptor-binding domain of SARS-CoV-2 elicits antibodies cross-neutralizing SARS-CoV-2 and SARS-CoV without antibody-dependent enhancement

J. Zang, C. Gu, B. Zhou, C. Zhang, Y. Yang, S. Xu, X. Zhang, Y. Zhou, L. Bai, Y. Wu, Z. Sun, R. Zhang, Q. Deng, Z. Yuan, H. Tang, , Z. Huang

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

bioRxiv · May 21, 2020Microbiology