A. Lee

This study investigates how lipid-based, protein-based, and steric interactions synergize to enable transmembrane signaling in mast cells through Ag-crosslinking of IgE-FcεRI.

The paper introduces Nuc-MS, a method to analyze protein composition of whole nucleosomes, revealing specific histone variants and modifications associated with oncogenic states.

This study identifies disulfiram as a novel inhibitor of Mtb's methionine biosynthesis, showing anti-tubercular effects through redox disruption and immune modulation.

This study shows metformin improves anti-mycobacterial responses by enhancing metabolic and functional properties of CD8+ T cells in mice and humans.

The paper develops a method to trace latently-infected HIV CD4 T cells to their original states using CyTOF, revealing the reservoir's conserved yet tissue-specific composition and enabling isolation of unstimulated latent cells.

The paper develops a dynamic EHT model to enhance contractile function and study desmosome-linked disease phenotypes in engineered heart tissues.

This study shows that adult muscle-derived stem cells can differentiate into cardiac pacemaker cells and improve heart rate in bradycardic mice.

This paper compares the quorum-sensing systems of Vibrio campbellii DS40M4 and BB120, finding genetic and functional differences in autoinducer production, regulatory mechanisms, and regulon size.

The paper uses transfer learning to predict specialized metabolism genes in tomato by leveraging annotations from Arabidopsis thaliana, improving prediction accuracy.

This study evaluates the effect of fractionated polymyxin B dosing on acute kidney injury in rats, finding that thrice-daily dosing caused the most kidney damage.

Marizomib inhibits primary tumor growth and reduces lung and brain metastases in pre-clinical triple-negative breast cancer models.

This study conducts a histone acetylome-wide association study (HAWAS) of tuberculosis, identifying differentially acetylated loci and their association with immune phenotypes.

The paper maps nucleosome barriers' topography and Pol II dynamics using single-molecule assays and reveals how H2A.Z and uH2B modify barrier height and width, affecting transcription.

This study identifies a putative enoyl-CoA hydratase involved in biofilm formation and antibiotic tolerance in Achromobacter xylosoxidans using a transposon mutagenesis approach.

This study shows aging increases adipose B cells and FALCs via Nlrp3 inflammasome, impairing metabolism, and B cell depletion improves metabolic function in aged mice.

This study examines microbial exchange between lung, oropharyngeal, and gastric microbiomes in children with impaired swallow function, finding increased similarity between lung and oropharyngeal microbiomes in those with aspiration.

This study examines how drought timing and severity impact Eastern Bluebird reproductive success using citizen science and climate data.

This paper introduces a tumor-specific causal inference framework to identify causative somatic genome alterations and their impact on molecular phenotypes in individual tumors.

This study shows that MFF-dependent mitochondrial fission limits axonal mitochondria size, which affects presynaptic release and axon branching by altering Ca2+ uptake capacity.