Identifying the causal allele in the CD40 autoimmune locus enables discovery of context-specific trans-effects in B cells
Yoshihiko Tomofuji, Zepeng Mu, Hafsa M. Mire, Yu Zhao, C.-J. Liu, Vidya Jayanthi, Nicholas W. Sugiarto, Accelerating Medicines Partnership: RA/SLE Network, Jeffrey A. Sparks, Soumya Raychaudhuri
The paper identifies a causal allele in the CD40 locus and demonstrates context-specific trans-effects in B cells using CITE-seq and CRAFT-seq.
bioRxiv · Aug 4, 2026 · PreprintGenetics