Q. Fang

The phylogenetic position of the Yunxian cranium elucidates the origin of Homo longi and the Denisovans

The study reconstructs the Yunxian 2 cranium and shows it belongs to the Homo longi clade, likely including Denisovans, and is closely related to the H. sapiens clade.

TRIP12 governs DNA Polymerase β involvement in DNA damage response and repair

This study identifies TRIP12 as a regulator of DNA polymerase β involvement in DNA damage response and repair by controlling its trafficking and chromatin loading.

Genomic signatures associated with the evolutionary loss of egg yolk in parasitoid wasps

This study identifies genomic signatures of yolk loss in parasitoid wasps, showing independent Vg gene loss events and associated functional biases in related genes.

Wide-field Intensity Fluctuation Imaging

This paper introduces a method to measure 2D intensity autocorrelation maps using ordinary cameras by modulating illumination with two pulses within a single exposure.

A parasitoid serpin gene that disrupts host immunity shows adaptive evolution of alternative splicing

The paper studies the evolution of alternative splicing and gene duplication in a parasitoid serpin gene, finding they jointly contribute to protein diversity and show divergent evolutionary patterns.

Characterizing Mineral Ellipsoids in New Bone Formation at the Interface of Ti6Al4V Porous Implants

This paper characterizes mineral ellipsoid packing at the bone-implant interface of Ti6Al4V porous implants using microscopy techniques and identifies orientation shifts that may contribute to bone strengthening.

Osseointegration of functionally-graded Ti6Al4V porous implants: Histology of the pore network

This study compares osseointegration of functionally-graded and uniform porous Ti6Al4V implants in rabbit tibiae, finding that smaller pores promote better bone volume and implant contact.

A compact breast shape acquisition system for improving diffuse optical tomography image reconstructions

This paper develops a compact breast shape acquisition system that improves diffuse optical tomography image reconstructions by reducing surface estimation errors and increasing absorption coefficient accuracy.

Simultaneous transcriptome and proteome profiling in a single mouse oocyte with a deep single-cell multi-omics approach

The paper develops a single-cell multi-omics platform to simultaneously profile transcriptome and proteome in mouse oocytes, revealing transcriptome-proteome heterogeneity and identifying maturational signatures.

Interpreting Inverse Correlation Time: from Blood Flow to Vascular Network

The paper redefines inverse correlation time (ICT) as reflecting both blood flow and vascular network structure, showing ICT sensitivity varies with vessel orientation.

Pick-up Single-Cell Proteomic Analysis for Quantifying up to 3000 Proteins in a Tumor Cell

The paper develops PiSPA, a single-cell proteomic workflow, to quantify up to 3000 protein groups in tumor cells, demonstrating its utility in studying single-cell proteome dynamics.

A genetic model for in vivo proximity labeling of the mammalian secretome

This paper introduces a genetic mouse model for in vivo proximity labeling of the secretome, revealing organ-specific secretory profiles and serum trafficking.

Signal and Measurement Considerations for Human Translation of Diffuse in vivo Flow Cytometry

This study evaluates the feasibility of detecting fluorescent signals from circulating cells in human blood vessels using diffuse in vivo flow cytometry (DiFC) by analyzing instrument geometry, wavelength, and tissue properties.

Framework for Denoising Monte Carlo Photon Transport Simulations Using Deep Learning

This paper develops a deep learning framework to denoise Monte Carlo photon transport simulations, significantly improving image quality and reducing computational costs.

Graphics processing unit-accelerated Monte Carlo simulation of polarized light in complex three-dimensional media

The paper develops a GPU-accelerated Monte Carlo method for simulating polarized light in 3D heterogeneous tissues, achieving a 931-fold speedup over CPU-based simulations.

BlenderPhotonics - an integrated open-source software environment for 3-D meshing and photon simulations in complex tissues

BlenderPhotonics provides an open-source tool for 3-D meshing and photon simulations in complex tissues using Blender and MMC, enabling user-friendly and efficient modeling.

MCX Cloud - a modern, scalable, high-performance and in-browser Monte Carlo simulation platform with cloud computing

MCX Cloud provides an open-source, web-based Monte Carlo simulation platform with cloud computing capabilities for biophotonics researchers.

Designing, optimizing, and assessing modular functional near-infrared brain imaging probes using an automated software workflow

The paper develops a software platform to design, characterize, and compare modular fNIRS probes, showing how different module configurations affect performance.

Temporal dynamics of base excision / single-strand break repair protein complex assembly and disassembly are modulated by the PARP1/NAD+/SIRT6 axis

The paper investigates the role of the PARP1/NAD+/SIRT6 axis in modulating the assembly and disassembly of DNA repair protein complexes during base excision repair.

Structural basis of substrate recognition and translocation by human ABCA4

This study presents cryo-EM structures of human ABCA4 in different states, revealing substrate recognition and translocation mechanisms.

Structure of the human SAGA coactivator complex

The paper presents the 2.9 Å structure of the human SAGA coactivator complex, revealing unique structural features and functional modules with implications for transcription and splicing in disease and cancer.

Light transport modeling in highly complex tissues using implicit mesh-based Monte Carlo algorithm

This paper introduces an efficient implicit mesh-based Monte Carlo method for simulating light transport in complex tissues, significantly reducing memory usage and computational time.

A hybrid mesh and voxel based Monte Carlo algorithm for accurate and efficient photon transport modeling in complex bio-tissues

This paper introduces a hybrid Monte Carlo algorithm for photon transport modeling in complex bio-tissues, improving accuracy and efficiency over voxel-based methods.

Accelerating Monte Carlo modeling of structured-light based diffuse optical imaging via "photon sharing"

This paper introduces an efficient Monte Carlo method for simulating spatially modulated light transport in 3D domains, achieving significant speedups in both forward and inverse problems.

Proteome-wide Prediction of Lysine Methylation Reveals Novel Histone Marks and Outlines the Methyllysine Proteome

The paper predicts lysine methylation sites using MethylSight and validates them with mass spectrometry, identifying 70 new histone marks and 50,000 non-histone sites.

Transcranial Photobiomodulation with Near-Infrared Light from Childhood to Elderliness: Simulation of Dosimetry

This study simulates t-PBM dosimetry across ages 5-85 using MC simulations and brain atlases, finding age-related decreases in energy deposition and ECT thickness correlations.

GPU-accelerated mesh-based Monte Carlo photon transport simulations

The paper introduces MMCL, a GPU-accelerated mesh-based Monte Carlo photon transport simulator, achieving up to 420x speedup over CPU-based methods.

Transplantation of human pluripotent stem cells overexpressing insulin/ERRγ can efficiently decrease the HbA1c levels of type 2 diabetes patient (Case #2-A)