R. Ge

Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders

The paper identifies three distinct brain maturational subtypes in youth with mood and anxiety disorders using neuroimaging data, showing differences in cortical-subcortical maturation and cognitive function.

S373P Mutation Stabilizes the Receptor-binding Domain of Spike Protein in Omicron and Promotes Binding

The paper investigates the effect of the S373P mutation on the stability and binding ability of the Omicron spike protein's RBD using AFM-SMFS and molecular dynamics simulations.

Lysine acetylation regulates antibiotic resistance in Escherichia coli

This study identifies acetylation as a regulatory mechanism in antibiotic resistance in E. coli, showing it negatively affects metabolism but positively influences motility, with PykF acetylation playing a key role.

Global Screening of Sentrin-Specific Protease Family Substrates in SUMOylation

The paper identifies 3,763 SUMO1 modification sites and their dependence on six SENP proteins, revealing SENP3's role in innate immunity through deSUMOylation of DHX15 and PCBP2.

In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling

This study validates novel BRM/BRG1 ATPase inhibitors as chemical probes for SWI/SNF chromatin remodeling and shows their therapeutic potential in BRG1-mut lung cancers.