Author
S. Zhang
Broad Institute
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2017-2026 · peak 81/yrCo-Author Collaboration Network
10 top collaborators · 41 mutual co-author links281 papers
Recent·Most cited
- MicrobiologybioRxivDOI 10.3389/fmicb.2019.00216
- BiochemistrybioRxiv
Proteasome Substrate Capture and Gate Activation by Mycobacterium tuberculosis PafE
K. Hu, J. B. Jastrab, S. Zhang…·H. Li
This study identifies PafE as an ATP-independent proteasome activator in M. tuberculosis, revealing its mechanism of substrate capture and gate activation through structural and functional analyses.
DOI 10.1074/jbc.ra117.001471 - Cancer BiologybioRxiv
Down-regulation of LRIG1 by miR-20a modulates gastric cancer multidrug resistance
L. Zhou, X. Li, F. Zhou…·X. Zou
This study identifies miR-20a/LRIG1/EGFR axis as a regulator of gastric cancer multidrug resistance and suggests it as a therapeutic target.
DOI 10.1111/cas.13538 - MicrobiologybioRxiv
First Draft Genome Sequence of the Pathogenic Fungus Lomentospora prolificans (formerly Scedosporium prolificans)
R. Luo, A. Zimin, R. Workman…·S. Salzberg
The paper reports the first draft genome sequence of Lomentospora prolificans, assembled using Illumina and Oxford Nanopore reads, resulting in a highly contiguous genome with 8,656 protein-coding genes.
DOI 10.1534/g3.117.300107 - Cancer BiologybioRxiv
The polyploid state plays a tumor suppressive role in the liver
S. Zhang, K. Zhou, X. Luo…·H. Zhu
This study shows that polyploidy in the liver suppresses tumorigenesis while hyperdiploidy accelerates it in mutagen and high fat models.
DOI 10.1016/j.devcel.2018.01.010 - MicrobiologybioRxiv
High Activity Of Selective Essential Oils Against Stationary Phase Borrelia burgdorferi As A Persister Model
J. Feng, S. Zhang, W. Shi…·Y. Zhang
This paper evaluates the activity of 34 essential oils against Borrelia burgdorferi stationary phase cells, identifying oregano, cinnamon bark, and clove bud as highly effective against persisters and biofilms, with carvacrol as the most active component.
DOI 10.3389/fmed.2017.00169 - EcologybioRxiv
The Kobresia pygmaea ecosystem of the Tibetan highlands – origin, functioning and degradation of the world’s largest pastoral alpine ecosystem
G. Miehe, P.-M. Schleuss, E. Seeber…·K. Wesche
This paper reviews the origin, functioning, and degradation of the Kobresia pygmaea ecosystem in the Tibetan highlands, identifying key factors affecting its resilience and carbon dynamics.
DOI 10.1016/j.scitotenv.2018.08.164 - MicrobiologybioRxiv
Identification of novel mutations associated with cycloserine resistance in Mycobacterium tuberculosis
S. Zhang, J. Chen, P. Cui…·Y. Zhnag
This study identifies 17 novel genes associated with D-cycloserine resistance in Mycobacterium tuberculosis through whole genome sequencing of resistant mutants.
DOI 10.1093/jac/dkx316 - MicrobiologybioRxiv
Varying Effects of Common Tuberculosis Drugs on Enhancing Clofazimine Activity in vitro
S. Zhang, W. Shi, J. Feng…·Y. Zhang
The paper investigates how common tuberculosis drugs affect clofazimine activity in vitro and explores its potential for treating multi-drug-resistant TB.
DOI 10.1038/emi.2017.24 - MicrobiologybioRxiv
Identification of drug candidates that enhance pyrazinamide activity from a clinical drug library
H. Niu, C. Ma, P. Cui…·Y. Zhang
This study identifies drugs that enhance pyrazinamide's anti-persister activity by screening a clinical drug library against M. tuberculosis cultures enriched with persisters.
DOI 10.1038/emi.2017.23 - MicrobiologybioRxiv
Activity of Sulfa Drugs and Their Combinations against Stationary Phase B. burgdorferi in vitro
J. Feng, S. ZHANG, W. Shi, Y. ZHANG
This study evaluates sulfa drugs and their combinations against stationary phase B. burgdorferi, finding that some combinations are more effective than single drugs but less than a positive control.
DOI 10.3390/antibiotics6010010