X. Tan

The paper reports cryoEM structures of the mitochondrial SAM complex from Myceliophthora thermophila, revealing its architecture and mechanism for substrate accommodation.

The paper identifies MTHFD1 as a target for broad antiviral therapy by screening bat cells with RNAi and CRISPR libraries against mumps and influenza viruses.

This study investigates ACE2 N-terminal fragments binding to SARS-CoV-2 Spike RBD using molecular dynamics simulations and peptide synthesis, finding that a 23-mer peptide fragment binds with micromolar affinity to insect-derived RBD but not HEK-expressed RBD.

This study evaluates the in vivo efficacy and PK/PD of KBP-7072, an aminomethylcycline antibiotic, in pneumonia and thigh infection models, showing significant dose-dependent reductions in CFUs and improved survival.

This study uses iTRAQ proteomics to analyze the HCC secretome, identifying CA2 as a diagnostic and prognostic biomarker with potential therapeutic implications.

The paper assesses changes in drifting fish egg composition and abundance in the Xijiang River after dam construction, linking these changes to environmental factors.

This study characterizes the colonization dynamics of Rhodopseudomonas palustris GJ-22 on tobacco phyllosphere and shows it induces plant resistance to Tobacco mosaic virus.

This study shows that transketolase in S. aureus affects stress response regulators, impacting bacterial proliferation during infection.

This study develops a GFP-compatible DiFC method to non-invasively monitor CTC burden and detect CTC clusters in a multiple myeloma xenograft model.

This paper introduces a new technique called Diffuse in vivo Flow Cytometry (DiFC) for detecting rare fluorescently-labeled circulating cells in mice without drawing blood, achieving high accuracy and speed.

This study shows that S. aureus isolates from CF patients have increased intracellular persistence and metabolic adaptations, suggesting an intracellular niche contributes to chronic lung infection.

This study shows PTEN regulates clathrin-coated pit dynamics by modulating PI(3,4,5)P3 levels, promoting short-lived signaling-capable CCPs in cancer cells.