A. Ghosh

This study shows that artificial selection in Drosophila melanogaster led to early chronotypes with enhanced masking and advanced entrainment phases, suggesting masking contributes to circadian phasing.

The paper validates G-quadruplex DNA structures under electrospray-compatible conditions and provides a database with associated data for MS-based screening assays.

This paper identifies a horizontally transferred DAPDC gene in Phaeodactylum tricornutum that exhibits substrate promiscuity in lysine biosynthesis.

The paper evaluates SOCS1 and SOCS3 expression in hepatocellular carcinoma and their correlation with oncogenic pathways, finding some genes predict prognosis when combined with SOCS1/SOC3 levels.

This study compares stress responses in yeast mitochondria caused by misfolded proteins targeted to the IMS or matrix using different signal sequences, revealing compartment-specific adaptations.

This paper applies quantum mechanics to population dynamics, showing that quantum tunneling explains unexpected probabilities in a standard ODE model and opens new ways to study rare events.

This study develops a mathematical model to analyze how pharmacological chaperones and interferons affect prion proliferation, finding interferons are more potent at lower doses but combined therapy offers greater benefits.

The paper measures fusion speeds of biomolecular condensates and finds they vary by two orders of magnitude, correlating with macromolecular packing density and structure.

The paper shows Dengue virus counteracts apoptosis-mediated DNA breakage in infected cells, promoting cell survival and virus replication.

The paper demonstrates phase behaviors in a minimal macromolecular system involving oppositely charged proteins and polyelectrolytes, revealing physical rules underlying membraneless organelles.

This study identifies NFATc as a non-canonical phenotypic stability factor that stabilizes hybrid epithelial/mesenchymal phenotypes by enabling coexistence and transitions between epithelial, mesenchymal, and hybrid states.

This study isolates and characterizes a novel endo-xylanase-producing strain of Bacillus velezensis AG20 from a cave, demonstrating its enzymatic properties and prebiotic/anti-proliferative potential.

This study investigates the dimerization of human DBNL and its impact on biological activity through biophysical and imaging techniques.

This paper identifies an allosteric hot-spot in ZAP-70's tandem-SH2 domain that regulates T-cell signaling by enabling cooperative ligand binding, with mutations disrupting this process and causing autoimmune arthritis.

This study shows that the primary cilium in quiescent myoblasts dampens proliferative signaling and represses G2/M transcriptional networks, contributing to cell cycle arrest.

This study shows proteasomal inhibition causes degradation of EBNA3A and EBNA3C viral oncoproteins via autophagy-lysosomal pathway, while EBNA3B remains stable, suggesting potential therapeutic use of proteasome inhibitors for EBV-related B-cell lymphomas.

This study uses smartphone touchscreen interactions to measure sleep-wake cycles, finding that phone use correlates with sleep timing but overestimates sleep duration.

This paper introduces a non-radioactive mass assay to measure phosphatidylinositol-5-phosphate (PI5P) levels in Drosophila cells and tissues with high sensitivity.

This study shows that BMI1 is overexpressed in CALM-AF10-positive leukemias and that inhibiting BMI1 with PTC209 or PTC596 reduces leukemia growth and prolongs survival.

This study identifies specific cholesterol binding sites in ApoA1 that drive structural changes from closed to open conformations, revealing a mechanism for cholesterol sequestration.

The paper uses molecular dynamics simulations to study Aβ1-40 fiber elongation, revealing non-productive binding modes as a key feature.