D. Cai

Thymidine Phosphorylase Promotes the Formation of Abdominal Aortic Aneurysm in Mice Fed a Western Diet

This study shows that TYMP promotes abdominal aortic aneurysm (AAA) in mice fed a Western diet by enhancing inflammation, thrombosis, and MMP2 activation while inhibiting vascular smooth muscle cell function.

A Dimerization-dependent Allosteric Activation for Receptor-like Kinase in Plants

The paper shows that FERONIA (FER) activates its homologs through dimerization-dependent allosteric activation, with ROS enhancing dimerization and impacting plant responses like ABA-mediated stomatal movement.

Metabolomics-assisted mechanism analysis of gamma-PGA synthesis regulated by PhoP in B. licheniformis

This study shows PhoP directly regulates {gamma}-PGA synthesis in B. licheniformis and indirectly affects it through glutamate transport, nitrogen utilization, and ammonia assimilation.

Surfactant protein A promotes atherosclerosis through mediating macrophage foam cell formation

This study shows that surfactant protein A promotes atherosclerosis by enhancing macrophage foam cell formation through increased CD36 expression.

YAP condensates are highly organized hubs for YAP/TEAD transcription

This study shows YAP forms organized condensates under Hippo pathway and actin tension, which stabilize YAP and recruit coactivators to enhance transcription.

Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis

This study shows that reduced GAS6 in synovial macrophages due to M1 polarization impairs efferocytosis, leading to inflammation and cartilage damage in obesity-associated osteoarthritis.

Utah Array Characterization and Histological Analysis of a Multi-Year Implant in Non-Human Primate Motor and Sensory Cortices

The paper characterizes the histological and material changes in a non-human primate brain after long-term Utah array implantation, finding significant neuron loss and electrode damage.

Mettl3-mediated m6A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration

This study shows that Mettl3-mediated m6A modification of Fgf16 limits cardiomyocyte proliferation and heart regeneration in mice.

DNA methylation in transposable elements disrupts the connection between three-dimensional chromatin organization and gene expression upon rice genome duplication.

This study investigates how DNA methylation in transposable elements disrupts the link between 3D chromatin organization and gene expression in rice after genome duplication.

ExoBow: A transgenic strategy to study CD63 exosomes in vivo

The paper introduces ExoBow, a transgenic mouse model that enables tracking of CD63+ exosomes in vivo to study inter- and intra-organ communication.

TRIPLE-NEGATIVE BREAST CANCER CELLS RECRUIT NEUTROPHILS BY SECRETING TGF-β AND CXCR2 LIGANDS

This study identifies that TNBC cells recruit neutrophils by secreting TGF-β and CXCR2 ligands, promoting tumor progression.

Cellular-scale silicon probes for high-density, precisely-localized neurophysiology

This paper introduces cellular-scale silicon probes for high-density neurophysiology recording in rats, demonstrating long-term stability and precise spatial registration.

Dual located WHIRLY1 affects salicylic acid homeostasis via coordination of ICS1, 1 PAL1 and BSMT1 during Arabidopsis plant aging

The paper shows that dual localization of WHIRLY1 affects salicylic acid homeostasis by regulating ICS1, PAL1, and BSMT1 during Arabidopsis aging, leading to altered senescence phenotypes.

RFEX: Simple Random Forest Model and Sample Explainer for non-Machine Learning experts

The paper introduces RFEX, a simple Random Forest explainer for non-ML experts, improving model and sample explainability with a tabular output and case study.

Multistep metabolic engineering of Bacillus licheniformis to improve pulcherriminic acid production

This paper improves pulcherriminic acid production in Bacillus licheniformis through multistep metabolic engineering, achieving a record yield of 556.1 mg/L.

Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression

This study shows YAP forms liquid-like condensates that reorganize genome topology to enable long-term target gene expression.

Enhanced Synthesis of Poly Gamma Glutamic Acid by Increasing the Intracellular Reactive Oxygen Species in the Bacillus licheniformis Δ1-pyrroline-5-carboxylate Dehydrogenase Gene ycgN Deficient Strain

This study shows that deleting the ycgN gene in B. licheniformis increases gamma-PGA synthesis by raising intracellular ROS levels through P5C accumulation.