NMNAT promotes glioma growth through regulating post-translational modifications of p53 to inhibit apoptosis
R. G. Zhai, J. Liu, Y. Zhu, X. Tao, K. Ruan, H. Wang
bioRxiv · May 12, 2021Cancer Biology
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K. Ruan
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2019-2021 · peak 3/yrCo-Author Collaboration Network
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TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS
K. M. Cunningham, K. Zhang, K. Ruan, K. Maulding, M. Senturk, J. Grima, H. Sung, Z. Zuo, H. Song, J. D. Rothstein, H. J. Bellen, T. Lloyd
This study identifies TFEB/Mitf mislocalization as a mechanism linking impaired nuclear import to autophagolysosomal dysfunction in C9-ALS.
bioRxiv · Jun 26, 2020Cell Biology
Repurposing low-molecular-weight drugs against the main protease of severe acute respiratory syndrome coronavirus 2
J. Gao, L. Zhang, X. Liu, F. Li, R. Ma, Z. Zhu, J. Zhang, J. Wu, Y. Shi, Y. Pan, Y. Ge, K. Ruan
The paper identifies low-molecular-weight drugs that inhibit SARS-CoV-2 main protease using a fragment-based approach, finding niacin and hit 1 bind to the catalytic pocket and leading to the discovery of four drug candidates.
bioRxiv · May 5, 2020Biochemistry
Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1
M. Lv, J. Gao, M. Li, R. Ma, F. Li, Y. Liu, M. Liu, J. Zhang, X. Yao, J. Wu, Y. Shi, Y. Tang, Y. Pan, Z. Zhang, K. Ruan
This paper investigates the ligand recognition mechanism of PHF20L1 Tudor1, revealing a pre-existing open conformation that enables binding to both methylated proteins and small molecules.
bioRxiv · Apr 29, 2020Biochemistry
A Genetically Encoded Trimethylsilyl 1D 1H-NMR Probe for Conformation Change in Large Membrane Protein Complexes
Q. Liu, Q.-t. He, X.-x. Lyu, F. Yang, Z.-l. Zhu, P. Xiao, Z. Yang, F. Zhang, Z.-y. Yang, X.-y. Wang, P. Sun, Q.-w. Wang, C.-x. Qu, Z. Gong, J.-Y. Lin, , J. Sun
The paper introduces a genetically encoded 1D 1H-NMR probe for studying conformational changes in large membrane protein complexes, demonstrating its effectiveness with minimal protein and time.
bioRxiv · Dec 18, 2019 · PreprintBiochemistry