L. Deng

This study shows that cell-ECM interactions in the fluidic phase determine epithelial structure topology and polarity through ECM topology and biomechanical cues.

This study engineers Yarrowia lipolytica to produce squalene by optimizing the mevalonate pathway, achieving a 28-fold increase in squalene yield.

The paper shows MDCK cells coordinate collagen I fiber assembly through motion, promoting branching morphogenesis, with cell contraction and actin cytoskeleton playing key roles.

This study compares protein and peptide fractionation methods for proteome analysis in yeast, finding that FASP-HpH provides the highest protein identification when using a high-resolution mass spectrometer.

The paper shows that lung type II alveolar epithelial cells induce IFN-beta and recruit CCR2+ monocytes to combat vaccinia virus infection.

This study shows cells can sense long-range biomechanical forces through the matrix to initiate distant mechanical communication, enabling coordinated self-assembly.

This study identifies fibrinogen binding and iron acquisition as key determinants of MRSA vaginal colonization using a mouse model and transcriptomic analysis.

This study characterizes the vaginal DNA virome in patients with non-female factor infertility and finds associations between viral community composition and bacterial dysbiosis.

BiasDB compiles and analyzes known biased GPCR ligands, offering a resource for medicinal chemistry and pharmacology.

This study compares biodegradable mulch film with polyethylene plastic film in cotton and maize, finding higher yield and water use efficiency with biodegradable film without residual pollution.

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

This paper engineers an acetyl-CoA metabolic shortcut in Yarrowia lipolytica to efficiently produce triacetic acid lactone from acetic acid, achieving a 8.5-fold increase in titer and 31.9% of theoretical yield.

The paper shows mitotic CDK promotes replisome disassembly, fork breakage, and complex DNA rearrangements via TRAIP-dependent ubiquitylation of CMG helicase.

The paper studies the yeast chromosome-segregation system using electron cryotomography and perturbations, revealing the structure and dynamics of kinetochore-microtubule interactions.