K. Kang

Caspase-1 activates gasdermin A in non-mammals

The paper shows that caspase-1 activates GSDMA in non-mammals like amphibians, reptiles, and birds, revealing an evolutionary shift in caspase-1's target gasdermin.

Oxalic acid binds to gustatory receptor Gr23a and inhibits feeding in the brown planthopper

The paper identifies oxalic acid as a ligand for the brown planthopper's gustatory receptor Gr23a, showing it inhibits feeding and is sensed by the receptor.

Clinical and immunological signatures of severe COVID-19 in previously healthy patients with clonal hematopoiesis

This study identifies clonal hematopoiesis as an independent risk factor for severe COVID-19 in previously healthy patients, revealing distinct immunological and epigenetic signatures.

Voxelated Bioprinting of Mechanically Robust Multiscale Porous Scaffolds for Pancreatic Islets

This paper introduces a 3D bioprinting technique called DASP to create mechanically robust, multiscale porous scaffolds for encapsulating human pancreatic islets to enable responsive insulin release.

Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF

This study identifies the molecular mechanism by which eRNAs stimulate Pol II pause release by interacting with NELF through unpaired guanosines.

Strain dynamics of specific contaminant bacteria modulate the performance of ethanol biorefineries

This study identifies specific contaminant bacteria that reduce ethanol fermentation efficiency and shows how their removal could significantly lower industry emissions.

Effects of active dry yeast on growth performance, rumen fermentation characteristics and slaughter performance in beef cattle

This study examines how adding active dry yeast to the diet of beef cattle affects their growth, rumen fermentation, and slaughter performance, finding that 4 g/head/d improves microbial composition and carcass weight compared to low nutrition.

Effects of agricultural fungicide use on Aspergillus fumigatus abundance, antifungal susceptibility, and population structure

This study examines the effects of agricultural fungicide use on Aspergillus fumigatus abundance, antifungal susceptibility, and population structure, finding low resistance rates and no significant genomic impact.

Predicting commercially available antiviral drugs that may act on the novel coronavirus (2019-nCoV), Wuhan, China through a drug-target interaction deep learning model

This study uses a deep learning model to predict antiviral drugs that may target the novel coronavirus 2019-nCoV, identifying atazanavir as the most potent inhibitor.

Hormone Receptor-status Prediction in Breast Cancer Using Gene Expression Profiles and Their Macroscopic Landscape

This study compares gene expression profiling (GEP) and immunohistochemistry (IHC) for predicting hormone receptor status in breast cancer, finding GEP provides more accurate classification and better prognostic value.

Global kinome silencing combined with 3D invasion screening of the tumor microenvironment identifies fibroblast-expressed PIK3Cδ involvement in triple-negative breast cancer progression

The paper identifies fibroblast-expressed PIK3Cδ as a key driver of triple-negative breast cancer progression through paracrine signaling and shows its prognostic significance.

IFN-γ selectively suppresses a subset ofTLR4-activated genes and enhancers to potentiate M1-like macrophage polarization

The paper shows IFN-γ suppresses specific TLR4-activated genes and enhancers to enhance M1-like macrophage polarization.