M. Kim

This study identifies the PPARγ/ETV2 axis as a novel pathway that suppresses endothelial-to-mesenchymal transition in pulmonary hypertension.

This study characterizes non-covalently associated streptavidin nanohubs as stable protein-network materials with properties similar to chemically bonded hydrogels.

This study identifies CPSF3 as a druggable target in pancreatic cancer by showing its inhibition disrupts histone processing and cell proliferation.

The paper investigates HIV-1 spike protein dynamics using cryo-EM and simulations, showing how tilting exposes the MPER to antibody attack and alters membrane fusion.

This study characterizes the tumor microenvironment of renal medullary carcinoma using genomic, metabolic, and single-cell RNA-sequencing data, identifying key molecular features and potential therapeutic targets.

This study analyzes the gut microbiota of western honeybees infected with Varroa destructor, finding altered bacterial and archaeal communities in larvae and adult bees.

This study develops lignin composites with oxygen-releasing nanoparticles to enhance wound healing through antioxidation and controlled oxygen delivery, showing improved tissue granulation and collagen remodeling.

The paper presents a standardized protocol and bioinformatic pipeline for detecting and quantifying mercury methylation genes (hgcAB) in metagenomes, showing comparable efficiency between single and co-assembly approaches.

The paper investigates two interaction surfaces between XPA and RPA in the preincision complex of nucleotide excision repair, showing their distinct roles in complex assembly and NER activity.

The paper determines the crystal structure of a C62S mutant of OspI, revealing its active site conformation and mechanism of deamidating Ubc13.

This study identifies STK25 as a kinase that phosphorylates PRKAR1A, inhibiting PKA signaling and reducing myocardial contractility in response to beta adrenergic stimulation.

This study shows dopamine reduces HGM-induced retinal vascular dysfunction by mitigating oxidative stress and mitochondrial damage in diabetic retinopathy.

The paper demonstrates the utility of multi-wavelength analytical ultracentrifugation for analyzing complex biopolymer mixtures and interactions.

The paper shows that mitochondrial stress increases proteasome activity via HSPB1 and PSMB9, which are regulated by EEF1A2 and localized near mitochondria to prevent protein aggregation.

This study develops a high-throughput UHPLC-MS method to screen fecal metabolites for gut metabolic health, identifying 28 metabolites with quantitative profiles in patients with alcohol-related liver disease and healthy controls.

This study improves automated white-matter tractography in lower-quality diffusion MRI data by training on high-quality Connectom data and manually annotated pathways.

The paper investigates the ion selectivity mechanism of TMEM175, showing that its unique hydrophobic constriction and electrostatic field enable K+ selectivity without a canonical filter.

This study shows that bacterial acetyltransferase effectors directly acetylate RIN4 T166, activating RPM1-dependent immunity in Arabidopsis, and that SOBER1 suppresses this by deacetylating the same residue.

This study identifies a temperature-sensitive mutation in CstF77 that impairs mRNA 3' end formation, reducing heat stress sensitivity in plants by limiting toxic HSP101 protein accumulation.

This study identifies integrin mechanotransduction as essential for directing cytotoxic secretion at the immune synapse, showing that mechanical forces from LFA-1 guide lytic granule fusion and cytotoxicity.

The paper investigates why different CFTR mutations respond variably to the pharmacological chaperone VX-809 by analyzing proteostasis interactions and degradation pathways.

This study identifies CD49a-expressing polyfunctional CD8 memory subsets in lung tissue that persist after influenza infection and exhibit diverse effector functions.

This study evaluates CT-P59's antiviral activity against Delta and its variants, showing reduced in vitro potency but effective in vivo neutralization and symptom remission in mice.

This study converts human primed pluripotent stem cells into trophoblast stem-like cells using BMP4 treatment, showing they resemble genuine trophoblast stem cells in morphology, gene expression, and differentiation potential.

This study tracks cow, pig, and human fecal pollution in lake water over time using metagenomics and benchmarks novel protocols against standard culture-based and qPCR tests for water quality monitoring.

This study investigates the conformation and dynamics of the denatured state ensemble (DSE) of a membrane protein in a native lipid bilayer, finding it is dynamic and partially expanded.

This study compares survival strategies of environmental and enteric E. faecalis isolates under freshwater conditions, finding similar decay rates but distinct rRNA:rDNA ratios and limited evidence of habitat adaptation.

This study evaluates CT-P59's efficacy against SARS-CoV-2 variants, showing reduced in vitro neutralization but effective in vivo therapeutic potential against the B.1.351 variant.

This study examines how anisogamy influences genetic variation in moss using UV sex chromosomes, finding sex-biased mutation and selection but no model explaining observed diversity ratios.

This paper introduces OSIV, a technique for quantitative blood flow vector mapping in vivo, demonstrating its ability to measure absolute flow velocity and direction without tracers or high-speed cameras.