M. Kim

This study shows that the mitochondrial ATP synthase subunit d (ATPd) is essential for Arabidopsis growth and heat stress tolerance, with knockdown plants showing reduced growth, increased ROS, and mitochondrial dysfunction.

Seq-Scope provides submicrometer-resolution spatial transcriptomics for single-cell and subcellular analysis by using barcoded clusters on an Illumina platform.

This paper evaluates an AAV-based COVID-19 vaccine in mice and non-human primates, showing sustained neutralizing antibodies and memory T-cells, with room-temperature stability and scalable production.

The paper shows that fructose 1,6-bisphosphate sensed by PKM2 regulates MyoD stability and myogenic differentiation by modulating Huwe1 localization.

The paper identifies key immune genes and develops a transcriptional deviance score to predict immune checkpoint inhibitor responses in melanoma patients.

This study shows that Sestrins maintain muscle stem cell quiescence and function by regulating mTORC1 signaling and metabolism, and their loss accelerates age-related deterioration.

This study introduces CoDEX, a framework that links gene-cluster patterns with genetic vulnerabilities in PDAC, revealing subtype-specific dependencies and their impact on tumor phenotypes.

This study evaluates lambda-carrageenan's antiviral effects against influenza and SARS-CoV-2, showing dose-dependent inhibition and protective effects in mice.

This study develops a murine model of synchronous melanoma to show that genetic differences between tumors create distinct immune microenvironments affecting immunotherapy response.

This study established tonsil epithelial cell-derived organoids and demonstrated their feasibility as an ex vivo model for SARS-CoV-2 infection.

This study investigates how the marine ciliate Mesodinium rubrum controls sequestered cryptophyte organelles, finding limited transcriptional control and significant gene expression from the prey.

This study shows CDK2 activity coordinates cell-cycle commitment and DNA replication timing, with commitment occurring before DNA replication.

This study identifies distinct palmitoyl-protein signatures in large and small cancer-derived extracellular vesicles using a novel proteomic approach.

This study identifies mTERF18/SHOT1 and ATAD3 homologs as critical for mitochondrial nucleoid organization and complex I biogenesis in Arabidopsis, leading to heat tolerance.

This study uses in silico drug repositioning to identify bortezomib as an inhibitor of GALNT14-driven lung cancer metastasis, validated through in vitro and in vivo experiments.

The paper shows that infant-directed speech and song across cultures share consistent acoustic features that can be reliably classified and are perceptible to listeners.

The paper investigates how TrkB signaling suppresses BMP-mediated tumor inhibitory activity by disrupting BMP receptor complex formation and downregulating RUNX3 and KEAP1.

This paper introduces a real-time PAUS system with fluence compensation and motion correction for quantitative molecular imaging, demonstrated in a murine drug delivery model.

The paper identifies E2F1b as a regulator of endoreplication oscillators in Drosophila salivary glands by controlling Cyclin E/Cdk2 activity and S phase timing.

The paper shows STRIPAK directs PP2A to dephosphorylate MAP4K4, promoting oncogenic transformation via YAP1 activation.

This study shows that short-term high fat diets impair intestinal repair by disrupting efferocytosis, leading to reduced IL-10 production and defective barrier repair.

This study introduces an optogenetic tool to increase the mitochondrial protonmotive force, demonstrating its role in stress resistance and metabolic outcomes.

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.

This study shows that GV1001 reduces ovarian follicle loss caused by bevacizumab in mice without affecting its anti-cancer effects.

This study shows the TRPV1 S1-S4 domain undergoes temperature-dependent conformational changes, suggesting it contributes to thermosensing.

This study examines cytokine network changes in HCC patients after TACE, finding decreased network modularity and increased scale-free properties over time, with specific cytokines linked to survival outcomes.