M. Kumar

This study compares the pathogenesis of SARS-CoV-2 variants in human ACE2-expressing mice, finding that some variants are more lethal and replicate more in the lungs and brain.

This study investigates the antiviral effects of remdesivir, nevirapine, and AZT on Chandipura virus replication and identifies remdesivir as the most potent inhibitor through molecular docking analysis.

This study shows that deleting Sorbs2 in cardiomyocytes causes dilated cardiomyopathy in mice, with defects in microtubule polymerization and structural proteins, and links Sorbs2 variants to human cardiac diseases.

This study develops a hybrid vaccine combining influenza VLPs with SARS-CoV-2 RBD and GM-CSF, showing protection against both viruses in mice.

This study analyzes the gut virome of an Indian population using metagenomics, identifying novel viral families and a core virome composition.

This paper shows grape seed extract (GSE) is more effective than chemical disinfectants at inactivating Tulane virus, a human norovirus surrogate, by causing virus aggregation.

This study shows quinacrine binds to FGFR1's kinase domain, inhibits its activity, and reduces phosphorylation, proliferation, and migration in cancer cells.

The paper quantitatively assesses the decline of grassland habitats in the upper Gangetic Plains over 30 years, finding a 57% reduction mainly due to conversion to croplands.

This study infects wild-type mice with SARS-CoV-2 variants to show B.1.1.7 and B.1.351 replicate more efficiently and induce stronger inflammatory responses than the original B.1 virus.

The paper investigates the function and recognition mechanism of M. tuberculosis ESX-1 virulence factor EspC and its interaction with EccA1 ATPase, identifying key binding regions and their impact on secretion.

This paper develops a synthetic 3D microfluidic platform to perfuse large engineered tissues, demonstrating viability and accelerated neural differentiation in perfused constructs.

This study shows that Artemisinin inhibits Plasmodium falciparum Ddi1, leading to ubiquitinated protein accumulation and impaired damage recovery.

This study reconstitutes MCS between ER and lipid droplets in vitro, showing Rab18 and phosphatidic acid regulate MCS formation in response to metabolic and immune signals.

This study shows that the ErpY-like lipoprotein of Leptospira binds complement regulators, activates the alternate pathway, and reduces membrane attack complex deposition, aiding immune evasion.

The study evaluates the safety of Pueraria tuberosa water extract on rat organs, finding no adverse effects at certain doses over specific periods.

This study identifies an effective ELQ prodrug that prevents Babesia erythrocytic development and protects against lethal infection in mouse models.

The paper identifies and characterizes 19 hexose transporters in Piriformospora indica, showing differential expression under various nutrient conditions and functional roles in carbohydrate uptake.

This study repositions Alisporivir, an anti-Hepatitis C drug, as a potential treatment for artemisinin-resistant malaria by targeting PfCyP-19B, which is overexpressed in resistant parasites.

This study shows that SARS-CoV-2 causes neuroinvasion and encephalitis in K18-hACE2 mice, leading to 100% mortality by day 6 post-infection.

The paper screens a novel azole library against Leishmania donovani to identify potent anti-leishmanial compounds.

This study shows that RelA-mediated Hfq hexamerization requires RNA binding to Hfq monomers, challenging the idea that only hexamers can bind RNA.

This study shows ADEP1 activates Leptospira ClpP1P2, disrupting proteostasis and inhibiting growth by altering peptidase activity and enabling proteolytic degradation of unfolded proteins.

This study identifies PDGF pathway activation as a key driver of rapid progression in IDH wild-type low-grade astrocytomas compared to mutant tumors.

This study shows that auranofin inhibits SARS-CoV-2 replication and reduces inflammation in human cells, suggesting its potential as a therapeutic option for COVID-19.

This study creates an atlas of S-acylation in Arabidopsis, identifying 5185 modified cysteines across 2643 proteins, highlighting its role in plant cell function and cellulose synthesis.

The paper identifies CREBBP/EP300 as radiosensitization targets in mutant tumors by inhibiting histone acetyltransferase, which represses homologous recombination and increases radiation sensitivity.

This study shows Adhatoda Vasica extract reduces hypoxia-induced mitochondrial dysfunction and inflammation in asthma models, offering potential for treating severe steroid-resistant asthma.

This study shows that ATM-deficient cancer cells are more sensitive to the combination of olaparib and AZD6738, leading to cell death.

This study shows TRF2 directly represses hTERT through G-quadruplex-dependent mechanisms, linking telomere regulation to telomerase activity in normal and cancer cells.

The paper evaluates molecular dynamics models of LC3B and analyzes 26 missense mutations to understand their impact on structure and function in cancer.