S. L. Schmid

CCDC32 stabilizes clathrin-coated pits and drives their invagination

This study identifies CCDC32 as an endocytic accessory protein that stabilizes clathrin-coated pits and drives their invagination, with mutations linked to cardio-facio-neuro-developmental syndrome.

Endocytosis gated by emergent properties of membrane-clathrin interactions

This paper models clathrin-mediated endocytosis to show that the switch between productive and abortive CCPs is an emergent property of clathrin-membrane interactions and EAPs.

Structure-based inhibitors reveal roles for the clathrin terminal domain and its W-box binding site in CME

The paper identifies the role of clathrin's N-terminal domain in CME and develops a peptide inhibitor that specifically blocks CME without affecting other endocytic processes.

FCHSD2 Controls Oncogenic ERK1/2 Signaling Outcome by Regulating Endocytic Trafficking

This study shows FCHSD2 regulates endocytic trafficking of EGFR and MET, affecting ERK1/2 signaling and tumor progression in NSCLC.

DASC, a sensitive classifier for measuring discrete early stages in clathrin-mediated endocytosis

The paper introduces DASC, a method to distinguish abortive clathrin coats from clathrin-coated pits in live-cell imaging, enabling sensitive analysis of CME progression in EAP knockdown conditions.

The mechanisms of dynamin-actin interaction

This study identifies a noncanonical role for dynamin in cell-cell fusion by directly bundling actin filaments through GTPase-dependent interactions.

ERK1/2-dependent activation of FCHSD2 drives cancer cell-selective regulation of clathrin-mediated endocytosis

The paper identifies ERK1/2-dependent activation of FCHSD2 as a mechanism regulating clathrin-mediated endocytosis in cancer cells, with implications for cancer progression and therapy.

Mutant p53 triggers a dynamin-1/APPL1 endosome feedback loop that regulates β1 integrin recycling and migration

This study identifies a feedback loop involving mutant p53, dynamin-1, and APPL1 endosomes that enhances β1 integrin recycling and cell migration in cancer.

A non-canonical role for dynamin-1 in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells

This study identifies a non-scission role for dynamin-1 in regulating early stages of clathrin-mediated endocytosis in non-neuronal cells through interactions with SNX9.

A high-throughput assay to identify robust inhibitors of dynamin GTPase activity

The paper develops a sensitive fluorescence assay to identify dynamin GTPase inhibitors and finds that existing compounds like Dynasore and Dyngo-4a do not inhibit basal activity.

Decoupling global biases and local interactions between cell biological variables

The paper introduces DeBias, a method to separate global biases from local interactions in cell biology data, showing global bias contains mechanistic insights.