S. Lee

This study shows taurine biosynthesis via ADO enhances NST in inguinal adipose tissue by remodeling chromatin to increase gene transcription for thermogenesis.

This study identifies AVRblb2 as an effector that targets CNGC channels via CaM/CML proteins to suppress PTI in plants.

This study uses nanovials to screen antigen-specific T cells based on affinity and function, identifying a more specific functional TCR repertoire than standard techniques.

This paper identifies and evaluates small-molecule inhibitors of SAMHD1 through a comprehensive screening pipeline, revealing a novel mode of inhibition and potential therapeutic applications.

This study investigates ZIKV-induced neuroinflammation in adult mice, finding that macrophage IL-1β expression and complement activation contribute to neuroinflammatory damage.

This study shows that absence of CYP8B1 increases brain chenodeoxycholic acid (CDCA) levels, reducing neuronal excitotoxicity and stroke infarct area in mice.

This study identifies the Siglec-sialic acid-axis as a target for innate immunotherapy in glioblastoma, showing that blocking Siglec-E enhances phagocytosis and T cell priming, leading to delayed tumor growth and prolonged survival.

The paper identifies contributions of non-synonymous, synonymous, and non-coding variants to recurrent biological processes in retinoblastoma progression using genomic and functional analyses.

This study identifies neural vulnerabilities in glioblastoma by analyzing patient samples and model systems, revealing drug targets and pathways that can be exploited for treatment.

This study shows neuronal E93 in Drosophila regulates adult metabolism and circadian rhythms by acting in GABA and MIP neurons, linking metamorphosis to metabolic homeostasis.

The paper shows HY5 regulates GLK transcription factors to control chloroplast development and hypocotyl elongation during light-induced seedling development in Arabidopsis.

This paper introduces a low-cost, wireless capillary rheometer for visualizing and measuring rheological properties of complex fluids.

This study uses cryo-EM to analyze wild-type and oncogenic KIT mutants, revealing structural changes and a potential therapeutic target in cancer.

The paper introduces ELIE, a solid-state instrument for detecting amino acids and informational polymers to search for life on icy moons, demonstrating single-molecule detection of L-proline.

The paper improves NMR structure calculation by incorporating hydrogen bond restraints and using ANSURR validation, resulting in more accurate SH2 domain structures.

This study shows that low-level atrazine exposure in mice impairs oocyte quality and worsens age-related aneuploidy, with effects lasting long after exposure ends.

This study identifies AOA-infecting viruses in nitrifying soils and shows their potential to influence host physiology through metabolic gene transfer.

The paper quantifies the contributions of triceps surae and Achilles tendon to ankle impedance during postural control and finds that tendon stiffness dominates above low loads.

This study identifies lomitapide, a cholesterol-lowering drug, as an mTORC1 inhibitor that induces autophagic cell death in cancer cells and enhances immune checkpoint blockade in preclinical models.

The paper shows that the inner nuclear membrane's lipid environment protects Sun2 from degradation by sensing diacylglycerol through an amphipathic helix, regulated by CTDNEP1 and lipin 1.

This study shows that pancreatic delta cells regulate the glycemic set point in mice by modulating beta cell insulin response through paracrine signaling.

The paper examines how a range-expanding oak gall wasp interacts with parasitoid wasps in its native and expanded ranges, finding reduced apparent competition due to phenological divergence of enemy assemblages.

This study identifies and characterizes ARG2, a gene conferring resistance to anthracnose disease in sorghum, showing its role in defense responses and growth advantages.

This study shows that ECPAS-mediated 26S proteasome disassembly into 20S and 19S subcomplexes occurs during glucose starvation, enhancing proteolysis and cell survival.

This paper introduces a method for high-fidelity optical diffraction tomography using non-toxic RI matching media to improve 3D refractive index reconstruction of live organisms.

DINAVID provides a cloud-based system for remote 3D microscopy image analysis and visualization, designed to handle large datasets and improve accessibility.

The paper identifies trogocytic-molting as a process where T cells release TCRs via microvilli, leading to increased surface TCRs and metabolic reprogramming to support clonal expansion.

This study identifies Pi23226, a Phytophthora effector that targets host ribosome biogenesis, inducing nucleolar stress and cell death to promote pathogenicity.

This paper develops a method to sort T cells based on cytokine secretion and surface markers using hydrogel nanovials, finding that polyfunctional cells are more common in CD4+ T cells and remain viable after sorting.

The paper compares chromatin accessibility and active transcription factors between invasive lobular and ductal breast carcinomas using ATAC-seq data from TCGA.