S. Lee

This study identifies CRISIS2, an RxLR effector from Phytophthora capsici, which suppresses plant immunity by interacting with PMA and BAK1, leading to cell death and enhanced pathogen virulence.

The paper identifies heterogeneous tuft cells in injured lungs that develop independently of Type 2 cytokines and are not essential for dysplastic repair.

This paper describes NBI-921352, a selective NaV1.6 inhibitor that prevents seizures in Scn8a gain-of-function mice and wild-type models, with better efficacy and tolerability than existing antiseizure drugs.

This study shows that human septins form octamer-based filaments that mediate actin-membrane anchoring, as demonstrated through various imaging and biophysical techniques.

This study identifies tomato SDG33 and SDG34 histone methyltransferases that regulate stress tolerance by modifying H3K4 and H3K36 methylation and expression of negative regulators.

This study shows that eosinophils migrate to the lungs early after Mycobacterium tuberculosis infection in mice and macaques, mediated by GPR183 and Ch25h, independent of CCR3.

The paper identifies circulating immune-cell clusters (CICs) composed of antigen-presenting cells and B cells in blood, showing increased frequency in COVID-19 patients.

This paper shows SARS-CoV-2 directly infects human microglia, causing pro-inflammatory activation and apoptosis, which may contribute to neurological issues in COVID-19 patients.

This study develops a technique to simultaneously quantify ankle, muscle, and tendon impedance in humans and validates its reliability.

The paper shows FXR1 alters ribosomes in quiescent leukemic cells, inducing stress signals to enable non-canonical translation for chemosurvival.

This study identifies de novo pyrimidine synthesis as a therapeutic target in IDH mutant gliomas, showing that DHODH inhibitors are effective in preclinical models.

The paper identifies LRRC15 as an inhibitory receptor that blocks SARS-CoV-2 spike-mediated entry in trans, primarily expressed in fibroblasts and not co-expressed with ACE2.

This study uses a two-phase plant-soil feedback experiment to assess how soil biota influence the invasion success of Phragmites australis in North American wetlands.

The paper examines how soil pH affects viral community structure at local and global scales, finding that pH significantly influences both prokaryotic and viral communities.

The paper shows that confined cell migration induces heterochromatin formation and alters chromatin accessibility, which affects migration speed and cellular functions.

This study identifies a 3D-specific mechanosensing mechanism in neural stem cells, showing that Egr1 mediates stiffness-dependent lineage commitment in a range more relevant to brain tissue.

This study shows APOBEC3B regulates R-loop homeostasis and contributes to mutagenesis in cancer by binding R-loops and altering their landscape.

This study creates a murine model with JAK2V617F in both hematopoietic and vascular cells, showing it mimics human MPN features like disease progression and cardiovascular issues.

This study shows that JAK2V617F mutant megakaryocytes accelerate hematopoietic aging by affecting HSC interactions and vascular niche function in a murine MPN model.

This study identifies SIRT5 as a desuccinylase that regulates LDHA succinylation, promoting prostate cancer metastasis and progression.

The paper develops a scalable method to produce hydrogel microparticles with localized surface chemistry for cell interfacing, achieving high throughput and precise shape and functionalization.

This study shows that co-culturing the anaerobic fungus Caecomyces churrovis with Methanobacterium bryantii increases transcription of carbohydrate binding modules and related enzymes, enhancing biomass breakdown and sugar uptake.

This paper optimizes Cas9 for Cryptococcus neoformans to enable efficient gene editing with short homology arms.

The paper shows bacterial microbiota induce localized IFN-lambda-driven antiviral defenses in intestinal epithelial cells, enhancing host resistance to enteric viruses.

This study shows that juvenile zebra finches' preference for their father's song during vocal learning predicts the accuracy of their song imitation in adulthood.

The paper reviews efforts to create human anatomical structures, cell types, and biomarkers tables and 3D reference organs to support a Human Reference Atlas, with use cases showing their utility in biomedical research.

This study develops and tests human embryonic stem cell-derived chondrocytes for long-term repair of porcine articular cartilage, showing improved functionality compared to current methods.

This study expands prime editing by linking reverse transcriptase to FnCas9(H969A) nickase, enabling more precise and extended target gene modifications.

The paper develops a label-free 3D segmentation method using deep learning to analyze live cells and their organelles without exogenous labels.