T. Suzuki

This study identifies protein-bound sialic acid (BSA) as a determinant of individual variation in salivary anti-influenza virus activity.

This study optimizes an LNP-mRNA vaccine targeting SARS-CoV-2 RBD by removing reactogenic materials, improving immunogenicity and protection in macaques.

This study shows SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking by inhibiting STAT1 nuclear translocation and binding importin 1, enhancing viral replication, particularly in older individuals.

The paper examines how naturally occurring mutations in SARS-CoV-2 spike proteins affect cell entry via ACE2 and TMPRSS2, finding that the D614G mutation increases infectivity but remains neutralization-sensitive.

This study identifies oxysterol derivatives with anti-SARS-CoV-2 activity, showing that Oxy210 and Oxy232 inhibit viral replication by disrupting double membrane vesicles.

This study shows that cynomolgus monkeys with lower peripheral T cell counts experience more severe pneumonia after SARS-CoV-2 infection compared to those with higher T cell counts.

This study shows FLT3-ITD accumulates in the Golgi apparatus in AML cells, activates signaling pathways like STAT5 and AKT/ERK during biosynthetic trafficking, and its tyrosine kinase activity is required for this retention.

This study shows that saffron and crocetin protect against motor symptoms, short lifespan, and rough-eyed phenotypes in Drosophila Parkinson's disease models.

This study compares antigen-specific antibody isotypes in COVID-19 patients to assess their kinetics, sensitivity, specificity, and correlation with neutralizing activity.

This study identifies Mefloquine as a potent in vitro entry inhibitor of SARS-CoV-2 with higher antiviral activity than Hydroxychloroquine.

This study shows SNAI1 represses let-7 miRNA, promoting stemness in cancer cells, and demonstrates nanoparticle-mediated SNAI1 knockdown reduces tumor burden.

The paper identifies key residues and an acyl-CoA-binding pocket in mouse LPCAT2 using homology modeling, providing structural insights for drug development against PAF-related diseases.

This study isolates and characterizes a novel phage SaGU1 that infects S. aureus clinical isolates from atopic dermatitis patients, showing it is safe and effective for phage therapy.

This study shows the SARS-CoV-2 D614G variant replicates more efficiently and transmits faster in hamsters than the wildtype virus.

The paper engineers high-affinity ACE2 receptors to neutralize SARS-CoV-2 in hamsters, showing protection against infection without viral escape mutations.

This study shows that c9,t11 CLA reduces amyloid-beta production in neurons by altering BACE1 and APP localization, potentially protecting against neurodegeneration.

This paper shows that SBHA reactivates KSHV in PEL cells through histone acetylation and induces apoptosis via the mitochondrial pathway, suggesting its potential as a therapeutic for PEL.

This study identifies MafF as an antiviral host factor that suppresses HBV core promoter transcription, contributing to host defense against HBV infection.

This study identifies BGLF2, an EBV tegument protein, as being encapsulated in exosomes that enhance viral infection by boosting gene expression and suppressing innate immunity.

This paper generates human bronchial organoids that support SARS-CoV-2 infection and drug testing, showing reduced viral load with TMPRSS2 inhibition.

This study identifies STING as a cargo of Golgi-to-ER transport and shows that impaired retrograde transport due to COPA syndrome mutations leads to STING activation and autoinflammation.

The paper shows that JMJ proteins remove repressive histone marks in Arabidopsis, enabling epigenetic memory of heat exposure to improve heat tolerance.

The paper identifies NRF2-CEBPB cooperativity in promoting tumor-initiating activity in NRF2-activated NSCLCs through enhancer remodeling and the NRF2-NOTCH3 regulatory axis.

This study identifies a new multidrug combination treatment for COVID-19 using nelfinavir and cepharanthine, showing synergistic antiviral effects and improved disease control.

This study visualizes female gametophyte development in Arabidopsis and identifies when and how cell fates are determined during its formation.

This study identifies a secreted β-1,4-glucanase gene involved in tissue adhesion between parasitic plants and hosts, revealing molecular similarities between parasitism and grafting.

This study identifies β-1,4-glucanases as facilitators of cell-cell adhesion in plant grafting, showing their role in promoting compatibility across species.

The paper identifies PLZF as a CRBN substrate degraded by thalidomide and 5-hydroxythalidomide, linking it to teratogenesis.

This study identifies HPnc4160, a small RNA in H. pylori, that negatively regulates host adaptation and gastric cancer by modulating gene expression and bacterial colonization.

This study shows that Klf5 downregulation in VSMCs leads to mitochondrial fission and senescence by reducing eIF5a, which preserves mitochondrial integrity.