M. Qin

Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

The paper develops methods to image glutamatergic synapses in hippocampal tissue using cryo-electron tomography, enabling high-resolution visualization of synaptic structures.

Alasemenia, the earliest ovule with three wings and without cupule

The paper describes a new Devonian ovule, Alasemenia tria, with three wings and no cupule, suggesting early evolution of wind dispersal mechanisms in seed plants.

RAG1 and RAG2 Non-core Regions Are Implicated in Leukemogenesis and Off-target V(D)J Recombination in BCR-ABL1-driven B-cell Lineage Lym-phoblastic Leukemia

This study shows that non-core RAG regions reduce off-target V(D)J recombination and maintain genomic stability in BCR-ABL1+ B-ALL by improving RAG cleavage accuracy.

PKA regulation of neuronal function requires the dissociation of catalytic subunits from regulatory subunits

This study shows that PKA catalytic subunits dissociate from regulatory subunits in neurons upon activation, which is necessary for synaptic plasticity and transmission.

Right atrial mechanism contributes to atrial fibrillation in a canine model of pulmonary arterial hypertension

CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

Temperature and Guanidine Hydrochloride effects on the folding thermodynamics of WW domain and variants

The paper calculates folding thermodynamics of WW domain variants using simulations and predicts effects of guanidine hydrochloride concentration changes.

Emergence of a Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Co-harbouring a blaNDM-1-carrying Virulent Plasmid and a blaKPC-2-carrying Plasmid in an Egyptian Hospital

This study identifies a hypervirulent CRKP strain in Egypt carrying two plasmids with carbapenemase and virulence genes, highlighting the genetic basis of resistance and virulence.

High-fidelity, efficient, and reversible labeling of endogenous proteins using CRISPR-based designer exon insertion

The paper introduces CRISPIE, a CRISPR-based method for precise, efficient, and reversible labeling of endogenous proteins by inserting designer exons into target genes.

Evaluation of Fecal Immunoassays for Canine Echinococcus Infection in China

This study evaluates three fecal immunoassay technologies for detecting canine Echinococcus infection in China, finding that sensitivity is lower than expected and further development is needed.

An Antioxidant Enzyme Therapeutic for COVID-19

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

Myristoylation alone is sufficient for PKA catalytic subunits to fractionally associate with the plasma membrane to regulate neuronal functions

The paper shows that myristoylation alone can drive membrane association of PKA-C, sufficient for regulating neuronal functions.

Transcriptome Analysis of xa5-mediated Resistance to Bacterial Leaf Streak in Rice (Oryza sativa L.)

The paper investigates the role of xa5 in BLS resistance by analyzing transcriptome changes in Xa5-RNAi rice lines compared to wild-type, finding enhanced cell death gene responses.