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This study shows that cardiac pericyte depletion in adult mice causes coronary endothelial leakage, cardiomyocyte dedifferentiation, and systolic/diastolic dysfunction.

This study investigates how chromosomal and gonadal sex affect lipid levels and hepatic gene expression in hypercholesterolemic mice under statin treatment.

This study identifies X chromosome dosage and DHA reduction as drivers of statin-induced dysglycemia and mitochondrial dysfunction in females.

This study examines changes in Glisson's capsule in liver disease, finding increased thickness and cellularity in cirrhosis regardless of cause, altered matrix composition, and reduced mechanical stiffness.

This study creates a single-nuclei cell atlas of the adult human adrenal gland and adrenocortical adenomas, revealing progenitor cell populations and tumor heterogeneity.

This study identifies Tmem100 as a lung-specific endothelial gene through single-cell RNA-sequencing analysis.

This study develops computational models to simulate sex differences in circadian regulation of kidney function in mice, revealing sex-specific effects on Na+ and K+ transport.

This study shows that changes in hERG1a/1b subunit abundance in hiPSC-CMs affect IKr sensitivity to protons, with mature cells showing reduced inhibition.

This study shows that arterial occlusion in mice leads to pericyte constriction and microcirculatory failure in peri-ischemic brain regions, impairing neurovascular coupling after reperfusion.

This study examines whether fiddler crabs can mobilize intracellular free amino acids during salinity challenges, finding asymmetrical FAA responses to hyper- and hypo-osmotic stress.

This study examines how systemic hypoxia alters fuel metabolism across organs, revealing distinct metabolic adaptations in acute versus chronic hypoxia.

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

This study shows liraglutide reduces diastolic dysfunction in mice by enhancing cardiac protein translation and amino acid uptake, but also causes muscle mass loss.

This study shows that reducing BIN1 levels in aged mice improves cardiac function and reverses aging-related defects.

This study shows that eliminating symbiotic bacteria in tsetse flies disrupts lipid metabolism via the Kennedy pathway, leading to reproductive failure.

This paper introduces a rapid bilevel optimization method to automate motion capture data processing, reducing manual effort and improving accuracy in biomechanical analysis.

The study shows that larger and better-conditioned bumble bee queens emerge later in spring, linking body size and condition to phenological timing.

This study evaluates boldine's effect on muscle atrophy in SCI mice, finding it does not prevent mass loss but modulates metabolome, transcriptome, and methylome changes.

This study shows that SUMOylation of Prox1 regulates hepatic cholesterol metabolism in response to fasting, with implications for metabolic health.