C. Wei

Esophageal epithelial Ikkβ deletion promotes eosinophilic esophagitis in experimental allergy mouse model

This study shows that deleting Ikkβ in esophageal epithelial cells worsens eosinophilic esophagitis in a mouse model, highlighting the importance of IKKβ/NFκB signaling in preventing allergic inflammation.

SWI/SNF chromatin remodeling determines brassinosteroid-induced transcriptional activation

This study shows that SWI/SNF chromatin remodeling is required for BZR1-mediated transcriptional activation in Arabidopsis thaliana.

Single-Cell Phylogenetic Tracing Maps the Landscape of Human Tumor Immune Cell Plasticity Driven by Microenvironment Factors-Mediated Epigenetic Reprogramming

This study maps immune cell plasticity in human tumors using lineage tracing and reveals microenvironment-driven epigenetic reprogramming as a key mechanism.

SARS-CoV-2 spike-induced syncytia are senescent and contribute to exacerbated heart failure

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

Correlation analysis between drug resistance and virulence genes of carbapenem-resistant Acinetobacter baumannii In Western Guilin

Truncated suPAR simultaneously causes kidney disease and autoimmune diabetes mellitus

The paper identifies a truncated suPAR fragment, D2D3, that causes kidney disease and autoimmune diabetes by impairing pancreatic beta-cell function and kidney health.

Self-similar tip growth links exocytosis profile with cell wall shape

The paper develops a mathematical framework to infer exocytosis profiles from cell morphology in self-similar tip-growing cells and applies it to experimental data across species.

Lyophilized mRNA-lipid nanoparticle vaccines with long-term stability and high antigenicity against SARS-CoV-2

This paper develops lyophilized mRNA-lipid nanoparticle vaccines that maintain stability at room temperature and show high antigenicity against SARS-CoV-2 variants in preclinical and human trials.

Metagenomics revealing molecular profiling of microbial community structure and metabolic capacity in Bamucuo, Tibet

This study uses metagenomics to characterize microbial community structure and metabolic capacity in Bamucuo, Tibet, identifying new species and metabolic pathways.

Evidence for a mouse origin of the SARS-CoV-2 Omicron variant

The paper investigates the origin of the SARS-CoV-2 Omicron variant, finding evidence suggesting it jumped from humans to mice and then back to humans.

Evaluation of podocyte Rac-1 induced kidney disease by modulation of TRPC5

This study evaluates the role of TRPC5 in podocyte Rac-1 induced kidney disease using transgenic mice and electrophysiological experiments, finding TRPC5 inhibition does not alleviate proteinuria.

Deep learning identifies pathological abnormalities predictive of graft loss in kidney transplant biopsies

This paper develops a deep learning model to quantify pathological features in kidney transplant biopsies, showing improved prediction of graft loss compared to clinical and Banff scores.

Fast Vesicle Fusion Mediated by Hydrophobic Dipeptides

The paper uses molecular dynamics simulations to show hydrophobic dipeptides facilitate vesicle fusion by forming hydrophobic stalks, reducing the free energy barrier for fusion.

SARS-CoV-2 manipulates the SR-B1-mediated HDL uptake pathway for its entry

This study shows SARS-CoV-2 uses the SR-B1-mediated HDL uptake pathway alongside ACE2 for entry, and blocking this pathway inhibits infection.

p38delta genetic ablation protects female mice from anthracycline cardiotoxicity

This study shows that deleting p38delta in female mice reduces anthracycline-induced cardiotoxicity by improving cardiac function and autophagy, while p38gamma deletion has no effect.

Alterations of human lung and gut microbiome in non-small cell lung carcinomas and distant metastasis

This study examines microbiome changes in lung and gut of NSCLC patients and finds sputum microbiota better predicts disease and metastasis than gut microbiota, with machine learning models achieving 0.842 AUC.

qKW9 encodes a pentatricopeptide repeat protein affecting photosynthesis and grain filling in maize

This study identifies qKW9, a gene affecting maize kernel weight by regulating photosynthesis through C-to-U editing of NdhB.

Experimental infection characteristics of Bordetella pertussis via aerosol challenge on rhesus macaques

This study evaluates aerosol challenge of rhesus macaques with B. pertussis, showing similar infection characteristics to humans and supporting their use as a pertussis model.