A. Kumar

This study identifies an N-terminal α-helix domain in PINK1 critical for its stabilization, autophosphorylation, and activation, linking mutations in this region to Parkinson's disease.

The paper shows that Esa1 acetylates Nup60 to regulate mRNA export and cell cycle progression in budding yeast.

This study compares the kinetic properties of plant and human DHAR enzymes, revealing differences in turnover rates and oxidation susceptibility that correlate with their cellular environments.

This study identifies two functional roles of EcGrx2: ascorbate recycling and ion channel activity, revealing its role in antioxidant defense and membrane integration in E. coli.

The paper screens surface lipoproteins of Leptospira to identify their roles in modulating host innate immune activation or evasion, finding that Loa22 strongly activates macrophages while Lsa30 is least stimulatory.

This study shows that the IRE1/XBP1 signaling pathway enhances skeletal muscle regeneration by boosting satellite cell proliferation in a cell non-autonomous way.

This study identifies critical residues in Plasmodium SUMO and Ubc9 that enable unidirectional cross-species interactions with human SUMOylation machinery, suggesting potential targets for antimalarial drugs.

This study assesses the safety of broadband laser exposure in μOCT on coronary and trachea tissues.

The paper develops a random forest classifier to predict R-loop binding proteins using proteomic features and amino acid composition, and validates new R-loop modulating proteins through CRISPR screening.

This study analyzes genetic diversity and population structure of 50 chickpea germplasms using ISSR markers, identifying diverse accessions for breeding and conservation.

The paper shows that sequence determines the fibril-forming structure in FUS-LC and its variants, with core-1 forming more readily than core-2.

This paper investigates the conformational dynamics of SARS-CoV-2 NSP6 protein, focusing on regions 91-112 and 231-290 outside the membrane, using molecular dynamics simulations and reductionist approaches.

This study demonstrates that stem cell-derived secretome reduces intraocular pressure and protects retinal ganglion cells in glaucoma models through COX2-PGE2 pathway activation and extracellular matrix remodeling.

This study shows that zinc ions inhibit SARS-CoV-2 main protease and viral replication in vitro, with structural evidence supporting the mechanism.

This paper develops a method to rapidly acquire multiple MRI maps by combining contrasts and reducing scan time using JVC-GRAPPA, achieving 6-minute scans with isotropic resolution.

This study investigates protein aggregation in SARS-CoV and SARS-CoV-2 proteomes, finding that several SARS-CoV-2 proteins form cytotoxic aggregates via a nucleation-dependent mechanism.

This study shows that MK2 and MK3 inhibition with CMPD1 reduces CHIKV infection by blocking actin remodeling and viral release, with potential for antiviral development.

This study shows SF3B1 mutations cause DYNLL1 mis-splicing, leading to genome instability through altered DNA repair and PARP inhibitor sensitivity.

The paper isolates and characterizes the SARS-CoV-2 VOC 20H/501Y.V2 (B.1.351) from UAE travelers to India to assess vaccine efficacy.

This study shows that STING mediates antibacterial immunity in the choanoflagellate M. brevicollis, a close relative of animals, and identifies its role in pathogen sensing and autophagy.

This study compares the pathogenicity of SARS-CoV-2 variants B.1 and B.1.617.1 in hamsters, finding B.1.617.1 causes greater body weight loss, higher viral load, and more severe lung lesions.

This study generates CCR5-edited T cells and macrophages from nonhuman primate iPSCs, showing resistance to SIV replication.

The paper designs a multi-epitope vaccine against human coronaviruses using in-silico tools, predicting epitopes and evaluating its antigenicity and immune response.

The paper examines the replication cycle and transcriptional patterns of the B.1.1.7 SARS-CoV-2 variant, finding higher expression of ORF6 and ORF8 and increased infectivity despite lower copy numbers.

The paper assesses timber, fuelwood, and fodder consumption patterns in forest fringe villages of Uttarakhand, India, finding high local extraction and socio-economic determinants of dependency.

This study shows that MHC-matched allogeneic bone marrow transplants in ART-suppressed SHIV-infected macaques do not fully eliminate viral reservoirs, with persistent SHIV DNA in tissues and rebound after ART interruption.

This study shows that NaCT-mediated citrate uptake supports cell survival under nutrient limitation and metal toxicity by enhancing metabolism and lipogenesis.

This study models neprilysin efficacy across species in degrading amyloid-beta peptides to inform Alzheimer's disease therapeutics.

The paper investigates the omnigenic effect of the OsNCED2T allele on qDTY12.1 grain yield under drought stress in rice and proposes a breeding model for drought tolerance.

The paper investigates the structural basis of phosphorylation kinetics in c-Jun's TAD and identifies two new phosphorylation sites.