A. Kumar

This study compares the pathogenicity and virus shedding of SARS-CoV-2 VOC 202012/01 and D614G variants in hamsters, finding higher viral shedding and mild lung pathology with VOC 202012/01.

The paper analyzes mitochondrial genomes of turtles and tortoises to compare adaptive selection patterns, finding stronger positive selection in turtles than tortoises.

The paper analyzes RNAseq data from cotton to identify gene modules associated with fiber development stages and links them to fiber-related traits.

This study shows that IFI16 senses Influenza A viral RNA, activates interferons and cytokines, and promotes pyroptotic cell death during infection.

This study identifies SARS CoV-2 nucleoprotein as an enhancer of spike-pseudotyped lentiviral particle infectivity without increasing sensitivity to RBD-based neutralization.

This study evaluates two doses of ZyCoV-D DNA vaccine in rhesus macaques, finding that the 2mg dose via Needle Free Injection System provides better immune response and protection against SARS-CoV-2.

This study identifies miR775 and its target GALT9 as regulators of submergence-induced senescence recovery in Arabidopsis by modulating SAGs and ROS levels.

This paper uses cryo-electron tomography to visualize how different Aβ assembly forms interact with lipid membranes, revealing that oligomers and protofibrils disrupt membrane integrity while monomers and fibrils have minimal impact.

This paper investigates how environmental factors affect the conformation of the C-terminal domain of the SARS-CoV-2 envelope protein, showing it transitions between disordered, membrane-bound, and amyloid states.

This study reprograms CRISPR-Cas13b to suppress SARS-CoV-2 replication and resist viral mutations by tolerating single-nucleotide mismatches.

This study investigates the amyloid-forming propensity of the Zika virus Capsid-anchor (CA) peptide and shows it forms cytotoxic amyloid-like fibrils.

This study examines ACE2 and TMPRSS2 expression in gastrointestinal tissues to understand their role in digestive symptoms, diabetes mortality, and disease recurrence in COVID-19.

This paper uses proximity labeling to identify KSHV vIRF-1 and vIRF-4 interacting proteins, revealing their roles in viral reactivation and innate immune regulation.

This study identifies the LigA surface protein's A11 domain as a key factor in Leptospira's ability to modulate host immune responses and evade complement-mediated killing.

The paper evaluates 90 nsSNPs in COPS2 using computational tools and molecular dynamics to identify pathogenic mutations affecting protein structure and function.

This study isolates and characterizes Lumpy Skin Disease Virus (LSDV) from cattle in India, showing it is closely related to Kenyan strains and demonstrating alternative cell lines for virus isolation and propagation.

This study investigates the conformational dynamics of SARS-CoV-2 nsp11 peptide under different membrane mimetics and solvent conditions, revealing its disordered nature and helical propensity in specific environments.

This study investigates the conformational dynamics of SARS-CoV-2 NSP1 C-terminal region in isolation and under different solvent environments, finding it intrinsically disordered with conformational changes induced by SDS, TFE, and DOPC.

The paper investigates how the ratio of hydrophobic-hydrophilic and positive-negative charged residues at the lipid-water interface affects TRPV1 surface expression and channel-gating.

This study identifies the secondary ossification center's role in protecting growth plate hypertrophic chondrocytes from mechanical stress during terrestrial adaptation.

This study analyzes HIV-1 env gene evolution in 12 perinatal transmission pairs, finding that most infections occur within two months of birth and fetal viruses show unique selection pressures.

This study investigates alternative catalytic mechanisms in HAS-GTPases, showing that structural plasticity allows GTP hydrolysis even when key residues are mutated.

This study investigates how sugar stereochemistry affects the structural and free energy landscapes of double-stranded nucleic acids using molecular dynamics simulations.

This study identifies a new mitochondrial lineage of red muntjac in Northwest India, revealing three genetic clusters and suggesting conservation actions for the Himalayan red muntjac.

This paper demonstrates that DABIL-4, a fusion toxin targeting IL-4R, effectively reduces TNBC tumor growth and metastasis by depleting both tumor cells and immunosuppressive cells in the tumor microenvironment.

This study shows that SWELL1 regulates endothelial AKT-eNOS and mTOR signaling, affecting vascular function and contributing to hypertension and vascular narrowing in Type 2 diabetes.

This study identifies the SWELL1-LRRC8 complex as a mechanosensor regulating skeletal muscle size, signaling, adiposity, and glucose metabolism through PI3K-AKT-mTOR pathways.

This study examines how hexaploid wheat responds to iron and phosphate deficiencies, finding that combined deficiencies rescue root growth inhibition and trigger specific gene and metabolite changes.

This study identifies novel tripeptides from goat urine that inhibit the AP-1 transcriptional complex, leading to reduced proliferation in HCT-116 cells.

This study shows mitochondrial and cytosolic reactive oxygen species are not required for HIF1α stability under hypoxia, suggesting HIF prolyl hydroxylase inhibition could be therapeutically beneficial.