Author

P. Chang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Biochemistry· 2 Cell Biology· 2 Plant Biology· 2 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 12 Research Focus:host-pathogen & immune response· 9 Assay:proteomics· 5 Research Focus:cell type annotation· 3 Organism:chicken / avian· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:clustering· 2

Frequent Co-Authors

M. Iqbal· 7 shared J.-R. Sadeyen· 6 shared S. Bhat· 5 shared J. E. Sealy· 4 shared R. Daines· 4 shared J. James· 3 shared M. J. Slomka· 3 shared B. Mollett· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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7 shared papersMicrobiology

M. Iqbal

Mutual co-authors in cluster

Author profile →

15 papers

Recent·Most cited

The Haemagglutinin Genes of the UK Clade 2.3.4.4b H5N1 Avian Influenza Viruses from 2020 to 2022 Retain Strong Avian Phenotype

J. Yang, R. Daines, P. Chang, T. K. Karunarathna, M. Qureshi, J.-R. Sadeyen, J. James, A. C. Banyard, M. J. Slomka, I. H. Brown, M. Iqbal

This study evaluates HA functionality of UK H5N1 avian influenza viruses from 2020-2022, finding they retain strong avian phenotype with low zoonotic threat.

bioRxiv · Jul 9, 2024 · PreprintMicrobiology

Molecular basis of the biogenesis of a protein organelle for ethanolamine utilization

M. Yang, O. Adegbite, P. Chang, X. Zhu, Y. Li, G. Dykes, Y. Chen, N. Savage, J. C. D. Hinton, L.-Y. Lian, L.-N. Liu

This study identifies the molecular mechanisms of Eut BMC assembly in Salmonella, revealing a 'Shell-first' pathway and the role of EutQ in cargo encapsulation and BMC formation.

bioRxiv · May 17, 2024Cell Biology

Human transmembrane protein 68 links triacylglycerol synthesis to membrane lipid homeostasis

F. Zeng, C. Heier, Q. Yu, H. Pang, F. Huang, Z. Zhao, P. Chang

This study identifies TMEM68 as a triacylglycerol synthase that regulates lipid metabolism and membrane lipid composition in neuro- and glioblastoma cells.

bioRxiv · Apr 14, 2024Biochemistry

Investigation of H9N2 avian influenza immune escape mutant that lacks haemagglutination activity

T. K. Karunarathna, J.-R. Sadeyen, S. Bhat, P. Chang, J. Yang, M. Qureshi, J. E. Sealy, R. Daines, M. Iqbal

This paper identifies an H9N2 avian influenza virus mutant with a G149E mutation in HA that loses haemagglutination activity but retains replication fitness, highlighting challenges for vaccine and surveillance efforts.

bioRxiv · Oct 3, 2023 · PreprintMicrobiology

Distribution and genetic diversity of South Florida Tephrosia shed light on past cultural use

E. J. von Wettberg, J. Sadle, E. Ogutcen, J. Possley, J. Lange, N. Carrasquila-Garcia, P. Chang

This study uses genetic analysis to trace the distribution and historical human use of Tephrosia angustissima in South Florida and the Caribbean.

bioRxiv · Jan 24, 2023 · PreprintPlant Biology

Risk Assessment of the newly emerged H7N9 avian influenza viruses

P. Chang, J.-R. Sadeyen, S. Bhat, R. Daines, A. Hussain, H. Yilmaz, M. Iqbal

This study assesses the zoonotic risk of recent H7N9 avian influenza viruses by analyzing their receptor binding, stability, and immune escape properties compared to earlier strains.

bioRxiv · Nov 11, 2022Microbiology

Optical Metabolic Imaging Uncovers Sex- and Diet-dependent Lipid Changes in Aging Drosophila Brain

Y. Li, P. Chang, S. Sankaran, H. Jang, Y. Nie, A. Zeng, S. Hussain, J. Y. Wu, X. Chen, L. Shi

This study uses optical metabolic imaging to show diet and sex influence lipid metabolism in aging Drosophila brains, revealing IIS pathway involvement.

bioRxiv · Oct 1, 2022 · PreprintBioengineering

Antigenic characterisation of human monoclonal antibodies for therapeutic use against H7N9 avian influenza virus

P. Chang, D. Lukosaityte, J. E. Sealy, P. Rijal, J.-R. Sadeyen, S. Bhat, S. Crossley, R. Daines, K.-Y. A. Huang, A. Townsend, M. Iqbal

This study characterizes human monoclonal antibodies against H7N9 avian influenza virus, identifies key epitopes, and evaluates escape mutants' impact on viral fitness and immune evasion.

bioRxiv · Sep 16, 2022 · PreprintMicrobiology

The origin of internal genes contributes to the replication and transmission fitness of H7N9 avian influenza virus

J. James, S. Bhat, S. K. Walsh, H. M. T. K. Karunarathna, J.-R. Sadeyen, P. Chang, J. E. Sealy, S. Mahmood, B. Mollett, M. J. Slomka, S. M. Brookes, M. Iqbal

This study shows that internal gene segments from different H9N2 lineages affect the replication and transmission fitness of H7N9 avian influenza viruses in chickens and their zoonotic potential.

bioRxiv · Aug 17, 2022Microbiology

The U1 snRNP component RBP45d regulates temperature-responsive flowering in Arabidopsis thaliana

P. Chang, H.-Y. Hsieh, S.-L. Tu

This study identifies RBP45d as a novel U1 snRNP component in Arabidopsis that regulates temperature-responsive flowering through alternative splicing of the FLOWERING LOCUS M gene.

bioRxiv · Jun 14, 2021Plant Biology

Co-infection of chickens with H9N2 and H7N9 avian influenza viruses leads to emergence of reassortant H9N9 virus with increased fitness for poultry and enhanced zoonotic potential

S. Bhat, J. James, J.-R. Sadeyen, S. Mahmood, H. Heverest, P. Chang, S. Walsh, A. M. Byrne, B. Mollett, F. Lean, J. E. Sealy, H. Shelton, M. J. Slomka, S. M. Brookes, M. Iqbal

bioRxiv · Apr 5, 2021Microbiology

Immunogenicity and Protective Efficacy of an Intranasal Live-attenuated Vaccine Against SARS-CoV-2 in Preclinical Animal Models

J.-G. Park, F. S. Oladunni, M. A. Rohaim, J. Whittingham-Dowd, J. Tollitt, B. M. Assas, W. Alhazmi, A. Almilaibary, M. Iqbal, P. Chang, R. Escalona, V. Shivanna, J. B. Torrelles, J. J. Worthington, L. H. Jackson-Jones, , M. Munir

This study evaluates an intranasal live-attenuated vaccine against SARS-CoV-2 in mice and hamsters, showing high immunogenicity and complete protection from disease and viral shedding.

bioRxiv · Jan 8, 2021Immunology

Proteomics of autophagy deficient macrophages reveals enhanced antimicrobial immunity via the oxidative stress response

T. Maculins, E. Verschueren, T. Hinkle, P. Chang, C. Chalouni, J. Lim, A. K. Katakam, R. C. Kunz, B. K. Erickson, T. Huang, M. Choi, T.-H. Tsai, O. Vitek, M. Reichelt, J. R. Rohde, , A. Murthy

This study shows that loss of Atg16l1 in macrophages enhances antimicrobial immunity against Shigella flexneri via the oxidative stress response.

bioRxiv · Sep 10, 2020Cell Biology

Temporal Effects on Radiation Responses in Nonhuman Primates: Identification of Biofluid Small Molecule Signatures by Gas Chromatography - Mass Spectrometry Metabolomics

E. Pannkuk, E. C. Laiakis, M. Girgis, S. Dowd, S. Dhungana, D. Nishita, K. Bujold, J. Bakke, J. Gahagen, S. Authier, P. Chang, A. J. Fornace

This study identifies small molecule signatures in nonhuman primate biofluids using GC-MS metabolomics to assess temporal radiation responses and metabolic changes following gamma-ray exposure.

bioRxiv · Apr 29, 2019Biochemistry

A capsular polysaccharide-expressing live vaccine suppresses streptococcal toxic shock-like syndrome and provides sequence type-independent protection during Streptococcus suis infection

Z. Li, P. Chang, J. Xu, X. Wang, W. Bei, C. Tan, J. Li

This paper develops a live attenuated S. suis vaccine by deleting multiple virulence genes, showing it suppresses STSLS and provides ST-independent protection in mice.

bioRxiv · May 31, 2018Microbiology